Emerging therapy for adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a very rare and aggressive tumor with dismal outcomes. Best current treatments include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination for advanced ACC. Advances in molecular genetic profiling o...

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Published inInternational journal of endocrine oncology Vol. 1; no. 2; p. 173
Main Authors Aufforth, Rachel D, Nilubol, Naris
Format Journal Article
LanguageEnglish
Published England 01.11.2014
Subjects
adrenocortical carcinoma
genomics
systemic treatment
molecular profiling
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Abstract Adrenocortical carcinoma (ACC) is a very rare and aggressive tumor with dismal outcomes. Best current treatments include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination for advanced ACC. Advances in molecular genetic profiling of ACC have created multiple new targets for potential treatment options in ACC. This article reviews the current treatment options available for ACC and discusses the potential new targets identified through molecular profiling.
AbstractList Adrenocortical carcinoma (ACC) is a very rare and aggressive tumor with dismal outcomes. Best current treatments include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination for advanced ACC. Advances in molecular genetic profiling of ACC have created multiple new targets for potential treatment options in ACC. This article reviews the current treatment options available for ACC and discusses the potential new targets identified through molecular profiling.
Author Nilubol, Naris
Aufforth, Rachel D
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  organization: Endocrine Oncology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
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Keywords adrenocortical carcinoma
genomics
systemic treatment
molecular profiling
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Title Emerging therapy for adrenocortical carcinoma
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