Tonifying qi and Warming yang, a compound traditional Chinese herbal medicine, suppresses AngII-induced cardiac H9c2 cells apoptosis through regulating PI3K/Akt signaling pathway

• Published in: Medicinal chemistry research Vol. 27; no. 2; pp. 366 - 373
• Main Authors: Zou, Guoliang, Zhong, Weili, Jin, Juan, Sui, Yanbo, Liu, Li
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2018; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Angiotensin II; Apoptosis; Bax protein; Bcl-2 protein; Biochemistry; Biomedical and Life Sciences; Biomedicine; Caspase-3; Cell Biology; Cytometry; Flow cytometry; Gene expression; Genes; Herbal medicine; Medicine; Membrane potential; Mitochondria; mRNA; Original Research; Pharmacology/Toxicology; Rats; Signal transduction; Signaling; Chinese herbal medicine; Tonifying qi and Warming yang; PI3K/Akt signaling pathway; AngII

This study aims to evaluate the effects of Tonifying qi and Warming yang on Ang II-induced cardiac apoptosis and mitochondrial dysfunction and to explore the underlying mechanism. Sprague Dawley (SD) rats were treated with Tonifying qi and Warming yang, and the drug-contained serum was used in our e...