Targeting of a novel Ca+2/calmodulin-dependent protein kinase II is essential for extracellular signal-regulated kinase-mediated signaling in differentiated smooth muscle cells

• Published in: Circulation research Vol. 97; no. 6; pp. 541 - 549
• Main Authors: Marganski, William A, Gangopadhyay, Samudra S, Je, Hyun-Dong, Gallant, Cynthia, Morgan, Kathleen G
• Format: Journal Article
• Language: English
• Published: United States 16.09.2005
• Subjects: Actinin - analysis; Actinin - metabolism; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases - analysis; Calcium-Calmodulin-Dependent Protein Kinases - chemistry; Calcium-Calmodulin-Dependent Protein Kinases - physiology; Cell Differentiation; COS Cells; Extracellular Signal-Regulated MAP Kinases - physiology; Ferrets; MAP Kinase Kinase 1 - analysis; MAP Kinase Kinase 2 - analysis; MAP Kinase Signaling System - physiology; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - physiology; Oligonucleotides, Antisense - pharmacology; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Vasoconstriction; Vimentin - analysis; Vimentin - metabolism

Subcellular targeting of kinases controls their activation and access to substrates. Although Ca2+/calmodulin-dependent protein kinase II (CaMKII) is known to regulate differentiated smooth muscle cell (dSMC) contractility, the importance of targeting in this regulation is not clear. The present stu...