Short‐chain fatty acids mediate gut microbiota–brain communication and protect the blood–brain barrier integrity

• Published in: Annals of the New York Academy of Sciences Vol. 1545; no. 1; pp. 116 - 131
• Main Authors: Chenghan, Mei, Wanxin, Li, Bangcheng, Zhao, Yao, He, Qinxi, Li, Ting, Zhang, Xiaojie, Li, Kun, Zhang, Yingqian, Zhang, Zhihui, Zhong
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2025
• Subjects: Acetic acid; Animals; Anti-Bacterial Agents - pharmacology; Antibiotics; Blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain - metabolism; Central nervous system; Claudin-5 - genetics; Claudin-5 - metabolism; Dysbacteriosis; Dysbiosis - metabolism; Endothelial cells; Fatty acids; Fatty Acids, Volatile - metabolism; Fatty Acids, Volatile - pharmacology; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - physiology; gut microbiome; Gut microbiota; Gut-brain axis; Humans; Integrity; Intestinal microflora; Macaca mulatta; Male; Membrane permeability; Mice; Mice, Inbred C57BL; Microbiota; Microorganisms; Monkeys; mRNA; Neurological diseases; Oral administration; propionate; Propionic acid; short‐chain fatty acids; Therapeutic targets; blood–brain barrier; gut microbiome; short‐chain fatty acids; antibiotics; propionate

The human gut, with a complex community of microbes, is essential for maintaining overall health. This gut microbiota engages in two‐way communication with the central nervous system, collectively known as the gut microbiota−brain axis. Alterations in gut microbiota have been associated with various...