Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis

• Published in: Journal of cerebral blood flow and metabolism Vol. 38; no. 7; pp. 1227 - 1242
• Main Authors: Veronese, Mattia, Reis Marques, Tiago, Bloomfield, Peter S, Rizzo, Gaia, Singh, Nisha, Jones, Deborah, Agushi, Erjon, Mosses, Dominic, Bertoldo, Alessandra, Howes, Oliver, Roncaroli, Federico, Turkheimer, Federico E
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2018
• Subjects: Acetamides - administration & dosage; Acetamides - pharmacokinetics; Administration, Oral; Adult; Cerebellum - diagnostic imaging; Cerebellum - metabolism; Frontal Lobe - diagnostic imaging; Frontal Lobe - metabolism; Humans; Kinetics; Male; Middle Aged; Models, Neurological; Original; Positron-Emission Tomography; Purines - administration & dosage; Purines - pharmacokinetics; Pyridines - administration & dosage; Pyridines - pharmacokinetics; Radioactive Tracers; Receptors, GABA - metabolism; kinetic modelling; endothelium; 3D modelling; TSPO; [11C]PBR28; immunohistochemistry; XBD173

The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central nervous system and represents the main target of radiotracers for the in vivo quantification of neuroinflammation with positron emission tomography (PET). TSPO PET is methodologically challenging given the hete...