Salivary Antimicrobial Peptide in Patients With Dementia Before and After Clinical Oral Rehabilitation Programme: A Randomised Controlled Trial

• Published in: Journal of oral rehabilitation Vol. 52; no. 1; pp. 1 - 8
• Main Authors: Chen, Ming‐An, Yang, Yuan‐Han, Liu, Ching‐Kuan, Matsuo, Koichiro, Hsu, Chih‐Cheng, Lin, Ying‐Chu, Huang, Hsiao‐Ling
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2025
• Subjects: Aged; Aged, 80 and over; Antimicrobial Peptides; cognitive ageing; Defensins; Dementia; Dementia - physiopathology; Dementia - rehabilitation; Dementia disorders; Female; hospitals; Humans; Male; Middle Aged; Oral Health; Oral Hygiene; Quality of Life; Rehabilitation; Saliva; Saliva - chemistry; Saliva - metabolism; Treatment Outcome; saliva; hospitals; oral health; rehabilitation; quality of life; cognitive ageing

ABSTRACT Background Emerging evidence suggests a link between salivary metabolite changes and neurodegenerative dementia, with antimicrobial peptides (AMPs) implicated in its pathogenesis. Objective We investigated the effects of a clinical oral rehabilitation programme tailored for dementia patient...