Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease

• Published in: Neurology Vol. 82; no. 15; p. 1362
• Main Authors: Donadio, Vincenzo, Incensi, Alex, Leta, Valentina, Giannoccaro, Maria Pia, Scaglione, Cesa, Martinelli, Paolo, Capellari, Sabina, Avoni, Patrizia, Baruzzi, Agostino, Liguori, Rocco
• Format: Journal Article
• Language: English
• Published: United States 15.04.2014
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Biomarkers - metabolism; Humans; Middle Aged; Nerve Fibers - metabolism; Nerve Fibers - pathology; Parkinson Disease - complications; Parkinson Disease - diagnosis; Parkinson Disease - metabolism; Parkinson Disease - pathology; Peripheral Nervous System Diseases - diagnosis; Peripheral Nervous System Diseases - etiology; Peripheral Nervous System Diseases - metabolism; Peripheral Nervous System Diseases - pathology; Phosphorylation; Skin - innervation; Skin - metabolism; Skin - pathology

To investigate (1) whether phosphorylated α-synuclein deposits in skin nerve fibers might represent a useful biomarker for idiopathic Parkinson disease (IPD), and (2) the underlying pathogenesis of peripheral neuropathy associated with IPD. Twenty-one well-characterized patients with IPD were studie...