Unraveling the connection between calreticulin and myeloproliferative neoplasms via calcium signaling

• Published in: Cell biology international Vol. 47; no. 7; pp. 1229 - 1246
• Main Authors: Jaiswal, Amit, Wang, Zhiguo, Xudong, Zhu, Ju, Zhenyu
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2023
• Subjects: Calcium - metabolism; Calcium imaging; calcium ion; Calcium Signaling; Calcium signalling; Calreticulin; Calreticulin - genetics; Calreticulin - metabolism; CRIPSR‐Cas9; CRISPR; essential thrombocythemia; GROMACS; Humans; Isoforms; Molecular dynamics; molecular dynamics simulation; Mutation; Myeloproliferative Disorders - pathology; Neoplasms; Thrombocythemia, Essential - pathology; Thrombosis; essential thrombocythemia; calcium ion; calreticulin; CRIPSR-Cas9; GROMACS; molecular dynamics simulation

Mutations in the form of insertions and deletions (INDEL) in the calreticulin gene lead to essential thrombocythemia (ET) which is characterized by the formation of thrombosis. However, the connection between calreticulin INDEL and ET remains largely elusive. Through combined molecular dynamics simu...