Elevated neutrophil extracellular trap levels in periodontitis: Implications for keratinization and barrier function in gingival epithelium

• Published in: Journal of clinical periodontology Vol. 51; no. 9; pp. 1210 - 1221
• Main Authors: Cui, Ya‐yun, Yang, Yi‐heng, Zheng, Jia‐yi, Ma, Hui‐hui, Han, Xue, Liao, Chong‐shan, Zhou, Min
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2024
• Subjects: Adult; Cadherins - analysis; Cadherins - metabolism; Calcium (intracellular); Calcium - analysis; Calcium - metabolism; Calcium permeability; Case-Control Studies; Cytokeratin; epithelial barrier; Epithelium; Extracellular Traps - metabolism; Female; Gene expression; Gingiva; Gingiva - metabolism; Gingival Crevicular Fluid - chemistry; Gum disease; human gingival keratinocytes; Humans; Intracellular; Keratinization; Keratinocytes; Keratinocytes - metabolism; Keratins - metabolism; KLF4 protein; Kruppel-Like Factor 4; Leukocytes (neutrophilic); Male; Middle Aged; mRNA; neutrophil extracellular traps; Neutrophils; Periodontics; Periodontitis; Periodontitis - immunology; Periodontitis - metabolism; Permeability; Saliva; Saliva - chemistry; Saliva - metabolism; Zonula occludens-1 protein; keratinization; neutrophil extracellular traps; epithelial barrier; human gingival keratinocytes; periodontitis

Aim To explore the levels of neutrophil extracellular traps (NETs) in patients with periodontitis and examine their effects on keratinization, barrier function of human gingival keratinocytes (HGKs) and the associated mechanisms. Materials and Methods Saliva, gingival crevicular fluid (GCF), clinica...