Phase III Intergroup Study of Fludarabine Phosphate Compared With Cyclophosphamide, Vincristine, and Prednisone Chemotherapy in Newly Diagnosed Patients With Stage III and IV Low-Grade Malignant Non-Hodgkin's Lymphoma

• Published in: Journal of clinical oncology Vol. 24; no. 10; pp. 1590 - 1596
• Main Authors: HAGENBEEK, Anton, EGHBALI, Houchingue, TEODOROVIC, Ivana, NEGROUK, Anastassia, VAN GLABBEKE, Martine, MARCUS, Robert, MONFARDINI, Silvio, VITOLO, Umberto, HOSKIN, Peter J, DE WOLF-PEETERS, Christiane, MACLENNAN, Ken, STAAB-RENNER, Elvira, KALMUS, Joachim, SCHOTT, Astrid
• Format: Journal Article
• Language: English
• Published: Baltimore, MD American Society of Clinical Oncology 01.04.2006; Lippincott Williams & Wilkins
• Subjects: Adult; Aged; Antimetabolites, Antineoplastic - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Cyclophosphamide - therapeutic use; Female; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Non-Hodgkin - drug therapy; Male; Medical sciences; Middle Aged; Neoplasm Staging; Prednisone - therapeutic use; Prospective Studies; Tumors; Vidarabine Phosphate - analogs & derivatives; Vidarabine Phosphate - therapeutic use; Vincristine - therapeutic use; Antineoplastic agent; Phase III trial; Phosphates; Early stage; Alkaloid; Cancerology; Lymphoproliferative syndrome; Malignant lymphoma; Advanced stage; Antimitotic; Low grade; Human; Corticosteroid; Purine nucleotide; Malignant hemopathy; Prednisone; Non Hodgkin lymphoma; Vincristine; Alkylating agent; Oxazaphosphinane derivatives; Chemotherapy; Cyclophosphamide; Fludarabine; Treatment; Antimetabolic; Nitrogen mustard; Adrenal hormone; Fluorine Organic compounds

To compare the efficacy and safety of fludarabine phosphate with cyclophosphamide, vincristine, and prednisone (CVP) in 381 previously untreated, advanced-stage, low-grade (lg) non-Hodgkin's lymphoma (NHL) patients in a phase III, multicenter study. Between 1993 and 1997, patients were randomly...