Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts

• Published in: Journal of cellular physiology Vol. 186; no. 3; pp. 371 - 379
• Main Authors: Li, Rongsong, Huang, Lei, Guo, Huiming, Toole, Bryan P.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.03.2001
• Subjects: 3T3 Cells; Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Base Sequence; Basigin; Blood Proteins; Cell Line; CHO Cells; Coculture Techniques; Cricetinae; DNA Primers; Fibroblasts - enzymology; Fibroblasts - physiology; Glycosylation; Humans; Matrix Metalloproteinases - genetics; Matrix Metalloproteinases - metabolism; Membrane Glycoproteins - genetics; Membrane Glycoproteins - physiology; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins - metabolism; Transfection; Tumor Cells, Cultured

Analysis of basigin‐null mice has shown that basigin is involved in several important physiological processes including reproductive, immune, and neural activities (Igakura et al., 1998, Dev Biol 194:152–165). However, its molecular mechanism of action in these processes has not yet been established...