Potentiation of slow component of delayed rectifier K+ currentby cGMP via two distinct mechanisms: inhibition of phosphodiesterase 3 and activation of protein kinase G

• Published in: British journal of pharmacology Vol. 137; no. 1; pp. 127 - 137
• Main Authors: Shimizu, Kentaro, Shintani, Yutaka, Ding, Wei‐Guang, Matsuura, Hiroshi, Bamba, Tadao
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2002
• Subjects: 8‐bromo‐cyclic GMP; atrial natriuretic peptide; cGMP; cyclic GMP‐inhibited phosphodiesterase; guinea‐pig; milrinone; protein kinase G; sino‐atrial node cells; Slowly activating component of delayed rectifier K+ current

Regulation of the slowly activating component of delayed rectifier K+ current (IKs) by intracellular guanosine 3′5′ cyclic monophosphate (cGMP) was investigated in guinea‐pig sino‐atrial (SA) node cells using the whole‐cell patch‐clamp method. When a cell was dialyzed with pipette solution containin...