Engineering metal-based hydrogel-mediated tertiary lymphoid structure formation via activation of the STING pathway for enhanced immunotherapy

• Published in: Materials horizons Vol. 10; no. 10; pp. 4365 - 4379
• Main Authors: Jin, Xiao-Kang, Liang, Jun-Long, Zhang, Shi-Man, Ji, Ping, Huang, Qian-Xiao, Qin, You-Teng, Deng, Xin-Chen, Liu, Chuan-Jun, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 02.10.2023
• Subjects: Antibodies; Chitosan; Dicarboxylic acids; Hydrogels; Imidazole; Immune system; Immunotherapy; Lymphocytes; Proteins; Stimulators; Tumors

Tertiary lymphoid structures (TLSs) primarily constructed by multiple immune cells can effectively enhance tumor immune responses, but expediting the formation of TLSs is still an enormous challenge. Herein, a stimulator of interferon gene (STING)-activating hydrogel (ZCCG) was elaborately developed...