Core–shell tecto dendrimers formed via host–guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery

• Published in: Nanoscale Vol. 11; no. 46; pp. 22343 - 22350
• Main Authors: Wang, Jianhong, Li, Du, Fan, Yu, Shi, Menghan, Yang, Yunxia, Wang, Le, Peng, Yitian, Shen, Mingwu, Shi, Xiangyang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 28.11.2019
• Subjects: Anticancer properties; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Assembly; Benzimidazoles - chemistry; beta-Cyclodextrins - chemistry; Cancer; Cell Survival - drug effects; Cyclodextrins; Dendrimers; Dendrimers - chemistry; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - metabolism; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug delivery systems; Drug Liberation; Encapsulation; Flow cytometry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hydrophobicity; Spheroids; Tumors; Viability

The design of pH-sensitive supramolecular drug delivery systems for efficient antineoplastic drug delivery remains a huge challenge. Herein, we describe the development of pH-responsive core–shell tecto dendrimers (CSTDs) formed using benzimidazole (BM)-modified generation 3 (G3) poly(amidoamine) (P...