Expeditious preparation of β- sec -alkyl vicinal amino alcohols used for chiral ligand synthesis

• Published in: Organic & biomolecular chemistry Vol. 21; no. 30; pp. 6111 - 6114
• Main Authors: Huang, Guoqi, Wu, Yu, Gong, Hegui, Chen, Yunrong
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 02.08.2023; Royal Society of Chemistry
• Subjects: Alcohols; Chemistry; Chemistry, Organic; L-Serine; Physical Sciences; Science & Technology; Steric hindrance; Synthesis; Threonine; CATALYSIS; POTENT; NICKEL; PHOTOREDOX; ACIDS; ARYLATION; ISOMERIZATION; ASYMMETRIC HYDROGENATION; DERIVATIVES; ALLYLAMINES

An economical route providing quick access to chiral β-amino alcohols bearing one β- sec -alkyl group was developed. This protocol starts with commercially available and cheap chiral sources such as derivatives of l -serine and l -threonine. A series of vicinal amino alcohols with high optical purit...