Post-walking exercise skeletal muscle perfusion and energetics in patients with symptomatic lower extremity peripheral artery disease

• Published in: Journal of nuclear cardiology Vol. 46; p. 102143
• Main Authors: Divakaran, Sanjay, Harms, Hendrik J., Robertson, Matthew, Merugumala, Sai K., Park, Mi-Ae, Kijewski, Marie F., Martell, Laurel B., Morgan, Victoria, Barrett, Leanne, Perillo, Anna, Yang, David, Jarolim, Petr, Feinberg, Mark W., Gerhard-Herman, Marie D., Belkin, Michael, Lin, Alexander P., Creager, Mark A., Bonaca, Marc P., Di Carli, Marcelo F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2025
• Subjects: Aged; Claudication; Exercise Test; Female; Humans; Intermittent Claudication - diagnostic imaging; Intermittent Claudication - physiopathology; Lower Extremity - blood supply; Magnetic Resonance Spectroscopy; Male; Microvascular disease; Middle Aged; Muscle, Skeletal - blood supply; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - metabolism; Muscle, Skeletal - physiopathology; Peripheral Arterial Disease - diagnostic imaging; Peripheral Arterial Disease - metabolism; Peripheral Arterial Disease - physiopathology; Peripheral artery disease; Phosphocreatine - metabolism; Positron Emission Tomography Computed Tomography; Prospective Studies; Skeletal muscle metabolism; Skeletal muscle perfusion; Walking - physiology; Peripheral artery disease; Claudication; Skeletal muscle perfusion; Microvascular disease; Skeletal muscle metabolism

The pathophysiology of symptoms and reduced exercise capacity from peripheral artery disease (PAD) remains unclear. Additionally, there is limited information on blood flow and skeletal muscle energetics after walking exercise in patients with claudication in comparison to healthy individuals. We pr...