Iron-catalysed enantioselective Suzuki-Miyaura coupling of racemic alkyl bromides

• Published in: Chemical communications (Cambridge, England) Vol. 55; no. 8; pp. 1128 - 1131
• Main Authors: Iwamoto, Takahiro, Okuzono, Chiemi, Adak, Laksmikanta, Jin, Masayoshi, Nakamura, Masaharu
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 25.01.2019; Royal Society of Chemistry
• Subjects: Bromides; Catalysis; Chemical industry; Chemistry; Chemistry, Multidisciplinary; Chirality; Cross coupling; Enantiomers; Iron chlorides; Lithium; Nonsteroidal anti-inflammatory drugs; Optical activity; Physical Sciences; Science & Technology; HALIDES; SECONDARY; ALPHA-BROMO ESTERS; METAL; CROSS-COUPLINGS; GRIGNARD-REAGENTS

The first iron-catalysed enantioselective Suzuki-Miyaura coupling reaction has been developed. In the presence of catalytic amounts of FeCl2 and (R,R)-QuinoxP*, lithium arylborates are cross-coupled with tert-butyl -bromopropionate in an enantioconvergent manner, enabling facile access to various op...