Antibodies against the calcium channel beta-subunit in Lambert-Eaton myasthenic syndrome

• Published in: Neurology Vol. 50; no. 2; p. 475
• Main Authors: Verschuuren, J J, Dalmau, J, Tunkel, R, Lang, B, Graus, F, Schramm, L, Posner, J B, Newsom-Davis, J, Rosenfeld, M R
• Format: Journal Article
• Language: English
• Published: United States 01.02.1998
• Subjects: Animals; Autoantibodies - blood; Blood Donors; Calcium Channels - analysis; Calcium Channels - immunology; Calcium Channels - metabolism; Calcium Channels, L-Type; Cell Membrane - metabolism; Cerebellum - metabolism; Cerebral Cortex - metabolism; Cloning, Molecular; Electrophysiology; Female; Humans; Lambert-Eaton Myasthenic Syndrome - diagnosis; Lambert-Eaton Myasthenic Syndrome - immunology; Lambert-Eaton Myasthenic Syndrome - physiopathology; Macromolecular Substances; Nerve Tissue Proteins - immunology; Rats; Rats, Inbred Lew; Recombinant Fusion Proteins - immunology; Reference Values

The sera of patients with Lambert-Eaton myasthenic syndrome (LEMS) contain autoantibodies against several extracellular and intracellular components of the voltage-gated calcium channel (VGCC)/synaptic vesicle release complex. An example of the latter are anti-beta-subunit antibodies (anti-MysB anti...