Recent advances in the synthesis of trifluoromethyl-containing heterocyclic compounds via trifluoromethyl building blocks

• Published in: Organic & biomolecular chemistry Vol. 22; no. 31; pp. 6246 - 6276
• Main Authors: Liu, Yaopeng, Tian, Qingyu, Ge, Jin, Wu, Xi, Li, Zhenghao, Cheng, Guolin
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 07.08.2024
• Subjects: Agrochemicals; Chemical reactions; Chemical synthesis; Heterocyclic compounds; Pharmacokinetics
• ISSN: 1477-0520; 1477-0539; 1477-0539
• DOI: 10.1039/D4OB00877D

Trifluoromethylated heterocyclic compounds have played an increasingly significant role in pharmaceuticals, agrochemicals, and materials. This is because the introduction of trifluoromethyl could enhance the lipophilicity, metabolic stability, and pharmacokinetic properties of heterocyclic drug mole...