A G-triplex based molecular beacon for label-free fluorescence "turn-on" detection of bleomycin

• Published in: Analyst (London) Vol. 143; no. 22; pp. 5474 - 5480
• Main Authors: Ma, Lin, Han, Xue, Xia, Lian, Kong, Rong-Mei, Qu, Fengli
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 05.11.2018
• Subjects: Antineoplastic Agents - blood; Antineoplastic Agents - chemistry; Assaying; Base Sequence; Benzothiazoles - chemistry; Bleomycin - blood; Bleomycin - chemistry; Chlorides - chemistry; Cleavage; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; Ferric Compounds - chemistry; Fluorescence; Fluorescent Dyes - chemistry; Humans; Inverted Repeat Sequences; Limit of Detection; Selectivity; Spectrometry, Fluorescence - methods

Since bleomycins (BLMs) play a prominent role in the clinical treatment of various cancers, the development of convenient and sensitive detection assays for BLM is of great significance in cancer therapy and related biological mechanism research. Here, taking advantage of the easily controllable and...