Development and validation of an LC-MS/MS method for quantifying a new G protein selective μ-opioid receptor agonist YZJ-4729 and its major metabolite M10 in human plasma to support a phase I study in healthy subjects - Ni, Yufeng; Ding, Chenxin; Cheng, Minlu; Ding, Li (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2025)
Keywords: Adult; Chromatography, Liquid - methods; Clinical pharmacokinetics; Humans; LC-MS/MS; Limit of Detection; Linear Models; Liquid Chromatography-Mass Spectrometry; Male; Metabolite; Receptors, Opioid, mu - agonists; Reproducibility of Results; Selective μ-opioid receptor agonist; Tandem Mass Spectrometry - methods; YZJ-4729; Selective μ-opioid receptor agonist; LC-MS/MS; YZJ-4729; Metabolite; Clinical pharmacokinetics