Silymarin exerts antioxidant and antiviral effects on Zika virus infection

• Published in: Journal of virological methods Vol. 335; p. 115133
• Main Authors: Lima, Rafaela Lameira Souza, Menegatto, Marília Bueno da Silva, Almeida, Letícia Trindade, Magalhães, José Carlos de, Ferraz, Ariane Coelho, Magalhães, Cintia Lopes de Brito
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2025
• Subjects: Animals; Antioxidant; Antioxidants - pharmacology; Antiviral; Antiviral Agents - pharmacology; Disease Models, Animal; Liver - drug effects; Liver - virology; Mice; Mice, Inbred C57BL; Oxidative Stress - drug effects; Silymarin; Silymarin - pharmacology; Viral Load - drug effects; Zika virus; Zika Virus - drug effects; Zika Virus Infection - drug therapy; Zika Virus Infection - virology; Antiviral; Zika virus; Silymarin; Antioxidant

The Zika virus (ZIKV) – Orthoflavivirus zikaense – epidemic and its association with severe neurological disorders have created an urgent need to understand the disease pathogenesis and identify potential therapeutic targets. In previous investigations, we have shown that oxidative stress is associa...