Placental cellular composition and umbilical cord tissue metal(loid) concentrations: A descriptive molecular epidemiology study leveraging DNA methylation

• Published in: Placenta (Eastbourne) Vol. 147; pp. 28 - 30
• Main Authors: Bulka, Catherine M., Rajkotwala, Husena M., Eaves, Lauren A., Gardner, Amaree J., Parsons, Patrick J., Galusha, Aubrey L., O'Shea, T. Michael, Fry, Rebecca C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 06.03.2024
• Subjects: Environmental chemicals; Placenta; Toxicology; Umbilical cords; LOD; Umbilical cords; Toxicology; ELGAN; Placenta; nRBC; Environmental chemicals

The placenta is a mixture of cell types, which may regulate maternal-fetal transfer of exogenous chemicals or become altered in response to exposures. We leveraged placental DNA methylation to characterize major constituent cell types and applied compositional data analysis to test associations with...