Effects of arachidonic acid, docosahexaenoic acid and prostaglandin E2 on cell proliferation and morphology of MG-63 and MC3T3-E1 osteoblast-like cells

• Published in: Prostaglandins, leukotrienes and essential fatty acids Vol. 76; no. 1; pp. 35 - 45
• Main Authors: Coetzee, M, Haag, M, Joubert, A.M, Kruger, M.C
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.01.2007
• Subjects: Advanced Basic Science; Biological and medical sciences; Endocrinology & Metabolism; Fundamental and applied biological sciences. Psychology; Vertebrates: endocrinology; Cell proliferation; Arachidonic acid derivatives; Polyunsaturated fatty acid; Prostaglandin E2; Lipids; Arachidonic acid; Docosahexaenoic acid; n-3 fatty acid; Osteoarticular system; n-6 fatty acid; Eicosanoid; Morphology; Osteoblast; Unsaturated fatty acid; Bone

Abstract During bone remodelling bone is resorbed by osteoclasts and replaced again by osteoblasts through the process of bone formation. Clinical trials and in vivo animal studies suggest that specific polyunsaturated fatty acids (PUFAs) might benefit bone health. As the number of functional osteob...