In vivo and in vitro metabolism of the novel synthetic cannabinoid 5F-APINAC

• Published in: Forensic toxicology Vol. 38; no. 1; pp. 160 - 171
• Main Authors: Appolonova, Svetlana A., Palacio, Covadonga, Shestakova, Ksenia M., Mesonzhnik, Natalia V., Brito, Alex, Kuznetsov, Roman M., Markin, Pavel A., Bochkareva, Natalia L., Burmykin, Dmitry, Ovcharov, Maxim, Musile, Giacomo, Tagliaro, Franco, Savchuk, Sergey A.
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 2020
• Subjects: Forensic Medicine; Forensic Science; Medical Law; Medicinal Chemistry; Medicine; Medicine & Public Health; Original Article; Pharmacology/Toxicology; New synthetic cannabinoid; Rat urine; APINAC; 5F-APINAC metabolites; LC–QTOF-MS/MS; Human liver microsomes (HLMs)

Purpose New generations of synthetic cannabinoids (SCs) have recognized strong psychoactive effects, rapidly becoming potent drugs of abuse. Characterization of metabolites associated with SCs is useful for their subsequent detection in biological samples. We aimed to investigate the metabolism of 5...