Cytotoxic and genotoxic evaluation and the toxicological mechanism of uranium in Vicia faba root
•Uranium induced apoptosis of root border cells in Vicia faba.•Uranium exposure damaged DNA and blocked the mitosis.•Uranium interfered with the antioxidant enzyme system and DNA repair system. This study revealed the cytotoxicity, genotoxicity and toxicity mechanism of uranium (U) in plants. The cy...
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| Published in | Environmental and experimental botany Vol. 179; p. 104227 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier B.V
01.11.2020
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| Abstract | •Uranium induced apoptosis of root border cells in Vicia faba.•Uranium exposure damaged DNA and blocked the mitosis.•Uranium interfered with the antioxidant enzyme system and DNA repair system.
This study revealed the cytotoxicity, genotoxicity and toxicity mechanism of uranium (U) in plants. The cytotoxic effect of U was evaluated by detecting the survival status of root border cells; the genotoxic effect was evaluated by micronuclear experiments; and the toxicity mechanism of U to plants was primarily revealed by combining with transcriptome. Results showed that after U exposure, the proportion of late apoptotic cells and dead cells was significantly higher than the control, indicating that U could induce the apoptosis or necrosis of root border cells. The micronucleus rate increased dramatically after U exposure, reaching a maximum of 4.89 times the control, whereas the mitotic index decreased significantly, reaching a minimum of 26.00% of the control. Moreover, the activities of superoxide dismutase and peroxidase decreased, triggering severe oxidative stress. Combined with the transcriptome data, this study showed that U interfered with the expression of genes related to antioxidant enzymes, the cell cycle and the DNA repair system. In conclusion, U strongly terminated the root border cells and blocked the mitosis, therefore inhibiting the growth of the Vicia faba root. It also caused DNA damage by interfering with the antioxidant enzymes to trigger oxidative stress and prevented DNA self-repair by interfering with the DNA repair system. |
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| AbstractList | •Uranium induced apoptosis of root border cells in Vicia faba.•Uranium exposure damaged DNA and blocked the mitosis.•Uranium interfered with the antioxidant enzyme system and DNA repair system.
This study revealed the cytotoxicity, genotoxicity and toxicity mechanism of uranium (U) in plants. The cytotoxic effect of U was evaluated by detecting the survival status of root border cells; the genotoxic effect was evaluated by micronuclear experiments; and the toxicity mechanism of U to plants was primarily revealed by combining with transcriptome. Results showed that after U exposure, the proportion of late apoptotic cells and dead cells was significantly higher than the control, indicating that U could induce the apoptosis or necrosis of root border cells. The micronucleus rate increased dramatically after U exposure, reaching a maximum of 4.89 times the control, whereas the mitotic index decreased significantly, reaching a minimum of 26.00% of the control. Moreover, the activities of superoxide dismutase and peroxidase decreased, triggering severe oxidative stress. Combined with the transcriptome data, this study showed that U interfered with the expression of genes related to antioxidant enzymes, the cell cycle and the DNA repair system. In conclusion, U strongly terminated the root border cells and blocked the mitosis, therefore inhibiting the growth of the Vicia faba root. It also caused DNA damage by interfering with the antioxidant enzymes to trigger oxidative stress and prevented DNA self-repair by interfering with the DNA repair system. |
| ArticleNumber | 104227 |
| Author | Chen, Xi Ma, Qiong Luo, Xue-gang Ji, Xiao-hui Lai, Jin-long Wu, Guo |
| Author_xml | – sequence: 1 givenname: Xi surname: Chen fullname: Chen, Xi organization: Life Science College, Sichuan Normal University, Chengdu, Sichuan 610101, China – sequence: 2 givenname: Guo surname: Wu fullname: Wu, Guo email: wuguoyk@163.com organization: Life Science College, Sichuan Normal University, Chengdu, Sichuan 610101, China – sequence: 3 givenname: Qiong surname: Ma fullname: Ma, Qiong organization: Life Science College, Sichuan Normal University, Chengdu, Sichuan 610101, China – sequence: 4 givenname: Jin-long surname: Lai fullname: Lai, Jin-long email: laijinlongswust@aliyun.com organization: Engineering Research Center of Biomass Materials, Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, China – sequence: 5 givenname: Xue-gang surname: Luo fullname: Luo, Xue-gang organization: Engineering Research Center of Biomass Materials, Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, China – sequence: 6 givenname: Xiao-hui surname: Ji fullname: Ji, Xiao-hui organization: College of Chemical and Environment Science, Shaanxi University of Technology, Hanzhong 723000, China |
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| Cites_doi | 10.1016/j.ceb.2009.01.017 10.1016/j.aquatox.2017.03.002 10.1016/j.mrrev.2019.108286 10.1016/j.jhazmat.2019.121437 10.1016/j.pbi.2013.06.010 10.1093/toxsci/kfj010 10.1016/j.envexpbot.2018.10.004 10.1107/S1600577517001850 10.1038/nmeth.3176 10.3390/toxics2010050 10.1093/jxb/ert375 10.1016/j.plaphy.2008.06.003 10.1093/nar/gkz1109 10.1016/j.envexpbot.2009.09.001 10.1016/j.envexpbot.2015.08.004 10.12659/MSMBR.893327 10.1080/10643389.2011.592761 10.1002/jat.3126 10.1016/j.ecoenv.2011.08.024 10.1016/S1369-5266(02)00282-0 10.1093/nar/gkt263 10.1021/acs.jmedchem.9b00083 10.1016/j.ecoenv.2019.06.048 10.1002/clen.201300297 10.1016/j.mrgentox.2016.07.006 10.3389/fpls.2019.01055 10.1111/nph.14865 |
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| References | Driouich, Follet-Gueye, Vicre-Gibouin, Hawes (bib0030) 2013; 16 Malaviya, Singh (bib0095) 2012; 42 Lai, Luo (bib0065) 2019; 181 Yan, Feng, Xiang, Liu, Wang, Xiao (bib0180) 2009; 29 Buchfink, Xie, Huson (bib0020) 2014; 12 Baxter, Mittler, Suzuki (bib0015) 2014; 65 Liu, Liu, Liu, Wu (bib0080) 2015; 21 Shino, Keisuke, Kyoko, Benjamin, Noriyoshi, Teruaki, Yasuko, Yoshiya (bib0145) 2015; 35 Zhong, Chen, Liu, Li, Tai (bib0200) 2012; 31 Liang, Shi, Zeng, Zhong, Yuan (bib0070) 2017; 78 Pereira, Camilleri, Floriani, Cavalié, Garnier-Laplace, Adam-Guillermin (bib0125) 2012; 2012 Monleau, De, Paquet, Chazel, Dumenil, Donnadieu-Claraz (bib0115) 2006; 89 Tewari, Horemans, Nauts, Wannijn, Hees, Vandenhove (bib0160) 2015; 120 Yin, Wang, Wang, Guo, Zhang, Ou, Huang, Wang, Tang, J.H (bib0185) 2019; 62 Lai, Liu, Luo (bib0060) 2020; 386 Davé Anoushka, Chen-Chun, Durley, Lydia, Sovan, Boon-Yu, Prudden, Tinline-Purvis, Cullen, Walker, Watson, Carr, Murray, Humphrey (bib0025) 2019; 48 Lourenco, Pereira, Silva, Carvalho, Oliveira, Malta, Paiva, Goncalves, Mendo (bib0090) 2012; 75 Serre, Alban, Bourguignon, Bourguignon, Ravanel (bib0140) 2019; 157 Ghosh, Jana, Sinha, Jothiramajayam, Nag, Chakraborty, Mukherjee, Mukherjee (bib0045) 2016; 807 Guo, Ding (bib0050) 2014; 2 Xu, Tang, Chen, Wang (bib0175) 2016; 36 Tang, Luo (bib0155) 2012 Kitahara, Numako, Terada, Nitta, Shimada, Homma-Takeda (bib0055) 2017; 24 Fu, Liu, Lai, Wu, Tao, Wang (bib0040) 2015; 34 Liu, Sun, Kong (bib0085) 2014; 26 Maria, Lucian, Igor (bib0100) 2008; 163 Mistry, Finn, Eddy (bib0110) 2013; 41 Feng, Wang, Li, Guo, Zhang, Cui (bib0035) 2017; 23 Missona, Henner, Morelloa, Floriani, Wu, Guerquin-Kernb, Février (bib0105) 2009; 67 Wang, Luo, Shi (bib0170) 2014; 34 Anna, Brietta, Susan (bib0005) 2009; 21 Liu, Wang, Li, Shen, Wang, Ye, Long, Song, Wu (bib0075) 2015; 43 Sidney (bib0150) 2014; 2 Zhao, Wang, Li, Gao, Cai, Zhang (bib0190) 2019; 32 Annamalai, Arunachalam (bib0010) 2017; 186 Vanhoudt, Vandenhove, Smeets, Remans, Hees, Wannijn, Vangronsveld, Cuypers (bib0165) 2008; 46 Roldan-arjona, Ariza, Cordoba-cañero (bib0130) 2019; 10 Serge, Florent, Claude, Nelson, Jacqueline, Sylvie, Anne-Marie, Richard, Marcel, Giovanni, Stéphane, Jacques (bib0135) 2018; 217 Zebian, Shaito, Mazurier, Rezvani, Zibara (bib0195) 2019; 782 Neill, Desikan, Hancock (bib0120) 2002; 5 Roldan-arjona (10.1016/j.envexpbot.2020.104227_bib0130) 2019; 10 Annamalai (10.1016/j.envexpbot.2020.104227_bib0010) 2017; 186 Davé Anoushka (10.1016/j.envexpbot.2020.104227_bib0025) 2019; 48 Malaviya (10.1016/j.envexpbot.2020.104227_bib0095) 2012; 42 Missona (10.1016/j.envexpbot.2020.104227_bib0105) 2009; 67 Shino (10.1016/j.envexpbot.2020.104227_bib0145) 2015; 35 Lai (10.1016/j.envexpbot.2020.104227_bib0060) 2020; 386 Anna (10.1016/j.envexpbot.2020.104227_bib0005) 2009; 21 Kitahara (10.1016/j.envexpbot.2020.104227_bib0055) 2017; 24 Liu (10.1016/j.envexpbot.2020.104227_bib0075) 2015; 43 Neill (10.1016/j.envexpbot.2020.104227_bib0120) 2002; 5 Baxter (10.1016/j.envexpbot.2020.104227_bib0015) 2014; 65 Vanhoudt (10.1016/j.envexpbot.2020.104227_bib0165) 2008; 46 Yan (10.1016/j.envexpbot.2020.104227_bib0180) 2009; 29 Xu (10.1016/j.envexpbot.2020.104227_bib0175) 2016; 36 Lourenco (10.1016/j.envexpbot.2020.104227_bib0090) 2012; 75 Fu (10.1016/j.envexpbot.2020.104227_bib0040) 2015; 34 Lai (10.1016/j.envexpbot.2020.104227_bib0065) 2019; 181 Tewari (10.1016/j.envexpbot.2020.104227_bib0160) 2015; 120 Zhong (10.1016/j.envexpbot.2020.104227_bib0200) 2012; 31 Maria (10.1016/j.envexpbot.2020.104227_bib0100) 2008; 163 Sidney (10.1016/j.envexpbot.2020.104227_bib0150) 2014; 2 Buchfink (10.1016/j.envexpbot.2020.104227_bib0020) 2014; 12 Liang (10.1016/j.envexpbot.2020.104227_bib0070) 2017; 78 Monleau (10.1016/j.envexpbot.2020.104227_bib0115) 2006; 89 Pereira (10.1016/j.envexpbot.2020.104227_bib0125) 2012; 2012 Yin (10.1016/j.envexpbot.2020.104227_bib0185) 2019; 62 Zhao (10.1016/j.envexpbot.2020.104227_bib0190) 2019; 32 Guo (10.1016/j.envexpbot.2020.104227_bib0050) 2014; 2 Driouich (10.1016/j.envexpbot.2020.104227_bib0030) 2013; 16 Liu (10.1016/j.envexpbot.2020.104227_bib0085) 2014; 26 Mistry (10.1016/j.envexpbot.2020.104227_bib0110) 2013; 41 Wang (10.1016/j.envexpbot.2020.104227_bib0170) 2014; 34 Liu (10.1016/j.envexpbot.2020.104227_bib0080) 2015; 21 Tang (10.1016/j.envexpbot.2020.104227_bib0155) 2012 Zebian (10.1016/j.envexpbot.2020.104227_bib0195) 2019; 782 Ghosh (10.1016/j.envexpbot.2020.104227_bib0045) 2016; 807 Serre (10.1016/j.envexpbot.2020.104227_bib0140) 2019; 157 Feng (10.1016/j.envexpbot.2020.104227_bib0035) 2017; 23 Serge (10.1016/j.envexpbot.2020.104227_bib0135) 2018; 217 |
| References_xml | – volume: 157 start-page: 121 year: 2019 end-page: 130 ident: bib0140 article-title: Uncovering the physiological and cellular effects of uranium on the root system of publication-title: Environ. Exp. Bot. contributor: fullname: Ravanel – volume: 62 start-page: 3147 year: 2019 end-page: 3172 ident: bib0185 article-title: Discovery of isaindigotone derivatives as novel Bloom's syndrome protein (BLM) helicase inhibitors that disrupt the BLM/DNA interactions and regulate the homologous recombination repair publication-title: J. Med. Chem. contributor: fullname: J.H – volume: 35 start-page: 1594 year: 2015 end-page: 1600 ident: bib0145 article-title: Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity publication-title: J. Appl. Toxicol. contributor: fullname: Yoshiya – volume: 807 start-page: 25 year: 2016 end-page: 32 ident: bib0045 article-title: Effects of ZnO nanoparticles in plants: Cytotoxicity, genotoxicity, deregulation of antioxidant defenses, and cell-cycle arrest publication-title: Mutat. Res-Gen. Toxicol. Environ. contributor: fullname: Mukherjee – volume: 41 start-page: 121 year: 2013 ident: bib0110 article-title: Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions publication-title: Nucleic Acids Res. contributor: fullname: Eddy – volume: 2012 start-page: 0 year: 2012 end-page: 16 ident: bib0125 article-title: Genotoxicity of uranium contamination in embryonic zebrafish cells publication-title: Aquat. Toxicol. contributor: fullname: Adam-Guillermin – volume: 43 start-page: 414 year: 2015 end-page: 420 ident: bib0075 article-title: Surface sediment contamination by uranium mining/milling activities in south China publication-title: Clean-Soil Air Water contributor: fullname: Wu – volume: 46 start-page: 987 year: 2008 end-page: 996 ident: bib0165 article-title: Effects of uranium and phosphate concentrations on oxidative stress related responses induced in publication-title: Plant Physiol. Biochem. contributor: fullname: Cuypers – volume: 782 year: 2019 ident: bib0195 article-title: XPC beyond nucleotide excision repair and skin cancers publication-title: Mutat. Res. contributor: fullname: Zibara – volume: 163 start-page: 475 year: 2008 end-page: 510 ident: bib0100 article-title: Characterization and remediation of soils contaminated with uranium publication-title: J. Hazard. Mater. contributor: fullname: Igor – volume: 65 start-page: 1229 year: 2014 end-page: 1240 ident: bib0015 article-title: ROS as key players in plant stress signalling publication-title: J. Exp. Bot. contributor: fullname: Suzuki – volume: 5 start-page: 388 year: 2002 end-page: 395 ident: bib0120 article-title: Hydrogen peroxide signalling publication-title: Curr. Opin. Plant Biol. contributor: fullname: Hancock – volume: 75 start-page: 0 year: 2012 end-page: 54 ident: bib0090 article-title: Evaluation of the sensitivity of genotoxicity and cytotoxicity endpoints in earthworms exposed in situ to uranium mining wastes publication-title: Ecotoxicol. Environ. Saf. contributor: fullname: Mendo – volume: 67 start-page: 353 year: 2009 end-page: 362 ident: bib0105 article-title: Use of phosphate to avoid uranium toxicity in publication-title: Environ. Exp. Bot. contributor: fullname: Février – volume: 31 start-page: 2404 year: 2012 end-page: 2411 ident: bib0200 article-title: DNA damage and DNA mismatch repair of plants under adverse circumstance stress: A review publication-title: Chin. J. Ecol. contributor: fullname: Tai – volume: 16 start-page: 489 year: 2013 end-page: 495 ident: bib0030 article-title: Root border cells and secretions as critical elements in plant host defense publication-title: Curr. Opin. Plant Biol. contributor: fullname: Hawes – volume: 42 start-page: 2575 year: 2012 end-page: 2647 ident: bib0095 article-title: Phytoremediation strategies for remediation of uranium-contaminated environments: A review publication-title: Crit. Rev. Environ. Sci. Technol. contributor: fullname: Singh – volume: 21 start-page: 237 year: 2009 end-page: 244 ident: bib0005 article-title: ATR/Mec1: coordinating fork stability and repair publication-title: Curr. Opin. Cell Biol. contributor: fullname: Susan – volume: 12 start-page: 59 year: 2014 end-page: 60 ident: bib0020 article-title: Fast and sensitive protein alignment using DIAMOND publication-title: Nat. Methods contributor: fullname: Huson – volume: 78 start-page: 1 year: 2017 end-page: 12 ident: bib0070 article-title: Spatial variation and assessment of heavy metal and radioactive risk in farmland around a retired uranium mine publication-title: Environ. Sci. Technol. contributor: fullname: Yuan – volume: 181 start-page: 491 year: 2019 end-page: 498 ident: bib0065 article-title: High-efficiency antioxidant system, chelating system and stress-responsive genes enhance tolerance to cesium ionotoxicity in Indian mustard ( publication-title: Ecotoxicol. Environ. Saf. contributor: fullname: Luo – volume: 29 start-page: 4215 year: 2009 end-page: 4222 ident: bib0180 article-title: Effects of uranium tail sand on growth and physiological characteristics of rape seedlings publication-title: Acta Ecol. Sin. contributor: fullname: Xiao – volume: 186 start-page: 145 year: 2017 end-page: 158 ident: bib0010 article-title: Uranium ( publication-title: Aquat. Toxicol. contributor: fullname: Arunachalam – volume: 120 start-page: 55 year: 2015 end-page: 64 ident: bib0160 article-title: Uranium exposure induces nitric oxide and hydrogen peroxide generation in publication-title: Environ. Exp. Bot. contributor: fullname: Vandenhove – volume: 89 start-page: 287 year: 2006 end-page: 295 ident: bib0115 article-title: Genotoxic and inflammatory effects of depleted uranium particles inhaled by rats publication-title: Toxicol. Sci. contributor: fullname: Donnadieu-Claraz – volume: 34 start-page: 2094 year: 2014 end-page: 2101 ident: bib0170 article-title: Characteristics of uranium uptake by pokeweed ( publication-title: Acta Sci. Circumst. contributor: fullname: Shi – volume: 217 start-page: 657 year: 2018 end-page: 670 ident: bib0135 article-title: plants challenged with uranium reveal new insights into iron and phosphate homeostasis publication-title: New Phytol. contributor: fullname: Jacques – volume: 34 start-page: 1646 year: 2015 end-page: 1652 ident: bib0040 article-title: Genotoxic effects of strontium on root tip cells of publication-title: J. Agro-Environ. Sci. contributor: fullname: Wang – volume: 2 start-page: 50 year: 2014 end-page: 78 ident: bib0150 article-title: The chemistry and toxicology of depleted uranium publication-title: Toxics. contributor: fullname: Sidney – volume: 10 start-page: 1055 year: 2019 ident: bib0130 article-title: DNA base excision repair in plants: An unfolding story with familiar and novel characters publication-title: Front. Plant Sci. contributor: fullname: Cordoba-cañero – volume: 36 start-page: 0370 year: 2016 end-page: 0376 ident: bib0175 article-title: Effect of uranium on photosynthesis of spinach leaves publication-title: Acta Bot. Boreali-Occid. Sin. contributor: fullname: Wang – volume: 32 start-page: 37 year: 2019 end-page: 40 ident: bib0190 article-title: Overview of detection techniques for micronucleus and chromosome aberration in eukaryotic cells publication-title: Chin. J. Ind. Med. contributor: fullname: Zhang – volume: 26 start-page: 1108 year: 2014 end-page: 1119 ident: bib0085 article-title: Advances in the stability maintenance mechanism of DNA replication fork in eukaryotic cells publication-title: Life Sci. contributor: fullname: Kong – volume: 48 start-page: 1271 year: 2019 end-page: 1284 ident: bib0025 article-title: Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks publication-title: Nucleic Acids Res. contributor: fullname: Humphrey – start-page: 128 year: 2012 end-page: 213 ident: bib0155 article-title: Experimental Course in Plant Physiology contributor: fullname: Luo – volume: 21 start-page: 15 year: 2015 end-page: 20 ident: bib0080 article-title: Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry publication-title: Med. Sci. Monit. Basic Res. contributor: fullname: Wu – volume: 24 start-page: 456 year: 2017 end-page: 462 ident: bib0055 article-title: Uranium xafs analysis of kidney from rats exposed to uranium publication-title: J. Synchrotron Radiat. contributor: fullname: Homma-Takeda – volume: 23 start-page: 5 year: 2017 end-page: 11 ident: bib0035 article-title: Research progress on Muts protein family in plant base mismatch repair system publication-title: Chin. Rice. contributor: fullname: Cui – volume: 2 start-page: 246 year: 2014 end-page: 249 ident: bib0050 article-title: Research progress of effects of heavy metal stress on biological DNA publication-title: Mod. Agric. Sci.Technol. contributor: fullname: Ding – volume: 386 year: 2020 ident: bib0060 article-title: A metabolomic, transcriptomic profiling, and mineral nutrient metabolism study of the phytotoxicity mechanism of uranium publication-title: J. Hazard. Mater. contributor: fullname: Luo – volume: 36 start-page: 0370 issue: 2 year: 2016 ident: 10.1016/j.envexpbot.2020.104227_bib0175 article-title: Effect of uranium on photosynthesis of spinach leaves publication-title: Acta Bot. Boreali-Occid. Sin. contributor: fullname: Xu – volume: 32 start-page: 37 issue: 01 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0190 article-title: Overview of detection techniques for micronucleus and chromosome aberration in eukaryotic cells publication-title: Chin. J. Ind. Med. contributor: fullname: Zhao – volume: 21 start-page: 237 issue: 2 year: 2009 ident: 10.1016/j.envexpbot.2020.104227_bib0005 article-title: ATR/Mec1: coordinating fork stability and repair publication-title: Curr. Opin. Cell Biol. doi: 10.1016/j.ceb.2009.01.017 contributor: fullname: Anna – volume: 186 start-page: 145 year: 2017 ident: 10.1016/j.envexpbot.2020.104227_bib0010 article-title: Uranium (238U) induced ROS and cell cycle perturbations, antioxidant responses and erythrocyte nuclear abnormalities in freshwater iridescent shark fish Pangasius sutchi publication-title: Aquat. Toxicol. doi: 10.1016/j.aquatox.2017.03.002 contributor: fullname: Annamalai – volume: 23 start-page: 5 issue: 05 year: 2017 ident: 10.1016/j.envexpbot.2020.104227_bib0035 article-title: Research progress on Muts protein family in plant base mismatch repair system publication-title: Chin. Rice. contributor: fullname: Feng – volume: 782 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0195 article-title: XPC beyond nucleotide excision repair and skin cancers publication-title: Mutat. Res. doi: 10.1016/j.mrrev.2019.108286 contributor: fullname: Zebian – volume: 386 year: 2020 ident: 10.1016/j.envexpbot.2020.104227_bib0060 article-title: A metabolomic, transcriptomic profiling, and mineral nutrient metabolism study of the phytotoxicity mechanism of uranium publication-title: J. Hazard. Mater. doi: 10.1016/j.jhazmat.2019.121437 contributor: fullname: Lai – volume: 16 start-page: 489 issue: 4 year: 2013 ident: 10.1016/j.envexpbot.2020.104227_bib0030 article-title: Root border cells and secretions as critical elements in plant host defense publication-title: Curr. Opin. Plant Biol. doi: 10.1016/j.pbi.2013.06.010 contributor: fullname: Driouich – volume: 2 start-page: 246 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0050 article-title: Research progress of effects of heavy metal stress on biological DNA publication-title: Mod. Agric. Sci.Technol. contributor: fullname: Guo – volume: 89 start-page: 287 issue: 1 year: 2006 ident: 10.1016/j.envexpbot.2020.104227_bib0115 article-title: Genotoxic and inflammatory effects of depleted uranium particles inhaled by rats publication-title: Toxicol. Sci. doi: 10.1093/toxsci/kfj010 contributor: fullname: Monleau – volume: 157 start-page: 121 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0140 article-title: Uncovering the physiological and cellular effects of uranium on the root system of Arabidopsis thaliana publication-title: Environ. Exp. Bot. doi: 10.1016/j.envexpbot.2018.10.004 contributor: fullname: Serre – volume: 26 start-page: 1108 issue: 11 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0085 article-title: Advances in the stability maintenance mechanism of DNA replication fork in eukaryotic cells publication-title: Life Sci. contributor: fullname: Liu – volume: 34 start-page: 2094 issue: 8 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0170 article-title: Characteristics of uranium uptake by pokeweed (Phytolacca Americana L.) and response of rhizosphere microbial community functional diversity publication-title: Acta Sci. Circumst. contributor: fullname: Wang – volume: 24 start-page: 456 issue: 2 year: 2017 ident: 10.1016/j.envexpbot.2020.104227_bib0055 article-title: Uranium xafs analysis of kidney from rats exposed to uranium publication-title: J. Synchrotron Radiat. doi: 10.1107/S1600577517001850 contributor: fullname: Kitahara – volume: 2012 start-page: 0 issue: 109 year: 2012 ident: 10.1016/j.envexpbot.2020.104227_bib0125 article-title: Genotoxicity of uranium contamination in embryonic zebrafish cells publication-title: Aquat. Toxicol. contributor: fullname: Pereira – volume: 12 start-page: 59 issue: 1 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0020 article-title: Fast and sensitive protein alignment using DIAMOND publication-title: Nat. Methods doi: 10.1038/nmeth.3176 contributor: fullname: Buchfink – volume: 2 start-page: 50 issue: 1 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0150 article-title: The chemistry and toxicology of depleted uranium publication-title: Toxics. doi: 10.3390/toxics2010050 contributor: fullname: Sidney – volume: 65 start-page: 1229 issue: 5 year: 2014 ident: 10.1016/j.envexpbot.2020.104227_bib0015 article-title: ROS as key players in plant stress signalling publication-title: J. Exp. Bot. doi: 10.1093/jxb/ert375 contributor: fullname: Baxter – volume: 46 start-page: 987 issue: 11 year: 2008 ident: 10.1016/j.envexpbot.2020.104227_bib0165 article-title: Effects of uranium and phosphate concentrations on oxidative stress related responses induced in Arabidopsis thaliana publication-title: Plant Physiol. Biochem. doi: 10.1016/j.plaphy.2008.06.003 contributor: fullname: Vanhoudt – volume: 48 start-page: 1271 issue: 3 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0025 article-title: Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz1109 contributor: fullname: Davé Anoushka – volume: 31 start-page: 2404 issue: 9 year: 2012 ident: 10.1016/j.envexpbot.2020.104227_bib0200 article-title: DNA damage and DNA mismatch repair of plants under adverse circumstance stress: A review publication-title: Chin. J. Ecol. contributor: fullname: Zhong – volume: 67 start-page: 353 year: 2009 ident: 10.1016/j.envexpbot.2020.104227_bib0105 article-title: Use of phosphate to avoid uranium toxicity in Arabidopsis thaliana leads to alterations of morphological and physiological responses regulated by phosphate availability publication-title: Environ. Exp. Bot. doi: 10.1016/j.envexpbot.2009.09.001 contributor: fullname: Missona – volume: 120 start-page: 55 year: 2015 ident: 10.1016/j.envexpbot.2020.104227_bib0160 article-title: Uranium exposure induces nitric oxide and hydrogen peroxide generation in Arabidopsis thaliana publication-title: Environ. Exp. Bot. doi: 10.1016/j.envexpbot.2015.08.004 contributor: fullname: Tewari – volume: 21 start-page: 15 year: 2015 ident: 10.1016/j.envexpbot.2020.104227_bib0080 article-title: Dual AO/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry publication-title: Med. Sci. Monit. Basic Res. doi: 10.12659/MSMBR.893327 contributor: fullname: Liu – volume: 42 start-page: 2575 issue: 24 year: 2012 ident: 10.1016/j.envexpbot.2020.104227_bib0095 article-title: Phytoremediation strategies for remediation of uranium-contaminated environments: A review publication-title: Crit. Rev. Environ. Sci. Technol. doi: 10.1080/10643389.2011.592761 contributor: fullname: Malaviya – volume: 35 start-page: 1594 issue: 12 year: 2015 ident: 10.1016/j.envexpbot.2020.104227_bib0145 article-title: Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity publication-title: J. Appl. Toxicol. doi: 10.1002/jat.3126 contributor: fullname: Shino – volume: 75 start-page: 0 year: 2012 ident: 10.1016/j.envexpbot.2020.104227_bib0090 article-title: Evaluation of the sensitivity of genotoxicity and cytotoxicity endpoints in earthworms exposed in situ to uranium mining wastes publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2011.08.024 contributor: fullname: Lourenco – volume: 5 start-page: 388 issue: 5 year: 2002 ident: 10.1016/j.envexpbot.2020.104227_bib0120 article-title: Hydrogen peroxide signalling publication-title: Curr. Opin. Plant Biol. doi: 10.1016/S1369-5266(02)00282-0 contributor: fullname: Neill – volume: 41 start-page: 121 issue: 12 year: 2013 ident: 10.1016/j.envexpbot.2020.104227_bib0110 article-title: Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt263 contributor: fullname: Mistry – volume: 62 start-page: 3147 issue: 6 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0185 article-title: Discovery of isaindigotone derivatives as novel Bloom's syndrome protein (BLM) helicase inhibitors that disrupt the BLM/DNA interactions and regulate the homologous recombination repair publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.9b00083 contributor: fullname: Yin – volume: 181 start-page: 491 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0065 article-title: High-efficiency antioxidant system, chelating system and stress-responsive genes enhance tolerance to cesium ionotoxicity in Indian mustard (Brassica juncea L.) publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2019.06.048 contributor: fullname: Lai – volume: 43 start-page: 414 issue: 3 year: 2015 ident: 10.1016/j.envexpbot.2020.104227_bib0075 article-title: Surface sediment contamination by uranium mining/milling activities in south China publication-title: Clean-Soil Air Water doi: 10.1002/clen.201300297 contributor: fullname: Liu – volume: 807 start-page: 25 year: 2016 ident: 10.1016/j.envexpbot.2020.104227_bib0045 article-title: Effects of ZnO nanoparticles in plants: Cytotoxicity, genotoxicity, deregulation of antioxidant defenses, and cell-cycle arrest publication-title: Mutat. Res-Gen. Toxicol. Environ. doi: 10.1016/j.mrgentox.2016.07.006 contributor: fullname: Ghosh – volume: 78 start-page: 1 year: 2017 ident: 10.1016/j.envexpbot.2020.104227_bib0070 article-title: Spatial variation and assessment of heavy metal and radioactive risk in farmland around a retired uranium mine publication-title: Environ. Sci. Technol. contributor: fullname: Liang – volume: 10 start-page: 1055 year: 2019 ident: 10.1016/j.envexpbot.2020.104227_bib0130 article-title: DNA base excision repair in plants: An unfolding story with familiar and novel characters publication-title: Front. Plant Sci. doi: 10.3389/fpls.2019.01055 contributor: fullname: Roldan-arjona – volume: 34 start-page: 1646 issue: 09 year: 2015 ident: 10.1016/j.envexpbot.2020.104227_bib0040 article-title: Genotoxic effects of strontium on root tip cells of Vicia faba L publication-title: J. Agro-Environ. Sci. contributor: fullname: Fu – volume: 163 start-page: 475 issue: 2 year: 2008 ident: 10.1016/j.envexpbot.2020.104227_bib0100 article-title: Characterization and remediation of soils contaminated with uranium publication-title: J. Hazard. Mater. contributor: fullname: Maria – volume: 217 start-page: 657 issue: 2 year: 2018 ident: 10.1016/j.envexpbot.2020.104227_bib0135 article-title: Arabidopsis thaliana plants challenged with uranium reveal new insights into iron and phosphate homeostasis publication-title: New Phytol. doi: 10.1111/nph.14865 contributor: fullname: Serge – volume: 29 start-page: 4215 issue: 08 year: 2009 ident: 10.1016/j.envexpbot.2020.104227_bib0180 article-title: Effects of uranium tail sand on growth and physiological characteristics of rape seedlings publication-title: Acta Ecol. Sin. contributor: fullname: Yan – start-page: 128 year: 2012 ident: 10.1016/j.envexpbot.2020.104227_bib0155 contributor: fullname: Tang |
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