Adaptive wheel exercise for mouse models of Parkinson’s Disease

• Published in: Journal of neuroscience methods Vol. 414; p. 110314
• Main Authors: Skelton, Henry, Grogan, Dayton, Kotlure, Amrutha, Berglund, Ken, Gutekunst, Claire-Anne, Gross, Robert
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2025
• Subjects: 6-hydroxydopamine; Animals; Disease Models, Animal; Electrophysiology; Exercise; Male; Mice; Mice, Inbred C57BL; Motor Activity - physiology; Motorized wheel; Oxidopamine - toxicity; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinsonian Disorders - physiopathology; Parkinsonian Disorders - therapy; Parkinson’s Disease; Physical Conditioning, Animal - methods; Physical Conditioning, Animal - physiology; Electrophysiology; Motorized wheel; Parkinson’s Disease; 6-hydroxydopamine; Mice; Exercise

Physical exercise has been extensively studied for its therapeutic properties in neurological disease, particularly Parkinson’s Disease (PD). However, the established techniques for exercise in mice are not well suited to motor-deficient disease-model animals, rely on spontaneous activity or force e...