The efficacy of infliximab for patients with rheumatoid arthritis in Japan: results of 5000 cases by post-marketing surveillance data
Aim: To clarify the efficacy of infliximab (INF) for active rheumatoid arthritis (RA) in Japan by nationwide postmarketing surveillance (PMS) data. Method: The data of 5000 cases with active RA, despite treatment with methotrexate, were collected to Tanabe Seiyaku Co., Ltd and all of these were an...
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Published in | APLAR journal of rheumatology Vol. 9; no. 2; pp. 142 - 145 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Melbourne, Australia
Blackwell Publishing Asia
01.08.2006
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Subjects | |
Online Access | Get full text |
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Summary: | Aim: To clarify the efficacy of infliximab (INF) for active rheumatoid arthritis (RA) in Japan by nationwide postmarketing surveillance (PMS) data.
Method: The data of 5000 cases with active RA, despite treatment with methotrexate, were collected to Tanabe Seiyaku Co., Ltd and all of these were analysed in detail for efficacy and adverse reactions. Overall efficacy was evaluated by physicians to three grades: markedly improved, improved and unchanged.
Results: Overall efficacy was 34.0% markedly improved, 57.6% improved and 8.4% unchanged at 22 weeks after INF therapy, respectively. Overall of adverse reactions were 28.0% and serious adverse reactions were 6.2%.
Conclusion: Iinfliximab was proven to be very effective and safe by nationwide PMS data in Japan. Longer observation is needed for further evaluation of INF therapy, especially efficacy forpreventing joint damage. |
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Bibliography: | istex:0407A75C79E64BC9B96E009689F4A30B96ECC244 ark:/67375/WNG-PJ43R7T5-7 ArticleID:APL198 |
ISSN: | 0219-0494 1479-8077 |
DOI: | 10.1111/j.1479-8077.2006.00198.x |