Cut‐Offs and Diagnostic Performance of IgG Against Recombinant Aspergillus fumigatus Antigens in Differentiating ABPA From Asthma

• Published in: Mycoses Vol. 68; no. 7; pp. e70087 - n/a
• Main Authors: Agarwal, Ritesh, Muthu, Valliappan, Sehgal, Inderpaul Singh, Prasad, Kuruswamy Thurai, Dhooria, Sahajal, Singh, Mani, Garg, Mandeep, Aggarwal, Ashutosh N., Rudramurthy, Shivaprakash M., Chakrabarti, Arunaloke
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2025
• Subjects: Adult; Allergic bronchopulmonary aspergillosis; allergic bronchopulmonary mycosis; allergy; Antibodies; Antibodies, Fungal - blood; Antigens; Antigens, Fungal - immunology; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary - blood; Aspergillosis, Allergic Bronchopulmonary - complications; Aspergillosis, Allergic Bronchopulmonary - diagnostic imaging; Aspergillosis, Allergic Bronchopulmonary - immunology; aspergillus; Aspergillus fumigatus; Aspergillus fumigatus - immunology; Asthma; Asthma - blood; Asthma - complications; Asthma - diagnostic imaging; Asthma - immunology; Bayesian analysis; Biomarkers - blood; bronchiectasis; Bronchiectasis - diagnostic imaging; Bronchiectasis - etiology; Case-Control Studies; Diagnosis, Differential; Enzyme immunoassay; Female; Humans; Immunoglobulin G; Immunoglobulin G - blood; Male; Mathematical models; Middle Aged; Prospective Studies; Radiography, Thoracic; Sensitivity and Specificity; allergy; asthma; aspergillus; bronchiectasis; allergic bronchopulmonary mycosis

ABSTRACT Background The diagnostic cut‐off values for IgG antibodies against recombinant Aspergillus fumigatus (rAsp) antigens in allergic bronchopulmonary aspergillosis (ABPA) remain unclear. Objectives To derive and validate diagnostic cut‐offs for IgG antibodies against rAsp f 1, f 2 and f 4 in A...