Development of a multiplex assay to assess activated p300/CBP in circulating prostate tumor cells

• Published in: Oncotarget Vol. 14; no. 1; pp. 738 - 746
• Main Authors: Filon, Mikolaj, Yang, Bing, Purohit, Tanaya A., Schehr, Jennifer, Singh, Anupama, Bigarella, Marcelo, Lewis, Peter, Denu, John, Lang, Joshua, Jarrard, David F.
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 20.07.2023
• Subjects: Acetylation; Histones - metabolism; Humans; Male; Neoplastic Cells, Circulating; p300-CBP Transcription Factors - metabolism; Prostatic Neoplasms, Castration-Resistant; Research Paper; Sirtuin 2; circulating tumor cells; p300/CBP; prostate cancer

Reduced SIRT2 deacetylation and increased p300 acetylation activity leads to a concerted mechanism of hyperacetylation at specific histone lysine sites (H3K9, H3K14, and H3K18) in castration-resistant prostate cancer (CRPC). We examined whether circulating tumor cells (CTCs) identify patients with a...