Faecalibacterium prausnitzii Suppresses Mitophagy to Alleviate Muscle Atrophy in Chronic Renal Failure With Protein‐Energy Wasting

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 133; no. 3; pp. e70014 - n/a
• Main Authors: Ni, Jingwen, Yin, Yuting, Liang, Pan, Zheng, Yuanyuan, Li, Yuying, Pang, Lvguang, Zhong, Xiaoshi, Hu, Jianguang
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.03.2025
• Subjects: Adenine; Animals; Atrophy; Casein; Cell Line; chronic renal failure; Creatinine; Dexamethasone; Disease Models, Animal; Faecalibacterium prausnitzii; Faecalibacterium prausnitzii - physiology; Failure; Gastrocnemius muscle; Kidney diseases; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - pathology; Male; Mitophagy; Muscle Proteins - genetics; Muscle Proteins - metabolism; Muscle, Skeletal - pathology; Muscles; Muscular Atrophy - pathology; Muscular Atrophy - therapy; Myotubes; Polymerase chain reaction; Probiotics; Protein-Energy Malnutrition - therapy; Proteins; protein‐energy failure; Rats; Rats, Sprague-Dawley; Renal failure; Reverse transcription; Tripartite Motif Proteins - genetics; Tripartite Motif Proteins - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Western blotting; protein‐energy failure; chronic renal failure; Faecalibacterium prausnitzii

ABSTRACT Protein‐energy wasting (PEW) facilitates major adverse clinical outcomes in chronic renal failure (CRF), with current therapies not suitable for all patients. Faecalibacterium prausnitzii (F. prausnitzii) can alleviate chronic kidney disease, with unclear effects and mechanisms on CRF with...