Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program

• Published in: Cell metabolism Vol. 34; no. 12; pp. 1906 - 1913
• Main Authors: Shapira, Suzanne N., Naji, Ali, Atkinson, Mark A., Powers, Alvin C., Kaestner, Klaus H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.12.2022
• Subjects: Diabetes Mellitus, Type 2; Epigenomics; Humans; islets; Pancreas; T2D; type 2 diabetes; epigenomics; type 2 diabetes; pancreas; islets; T2D
• ISSN: 1550-4131; 1932-7420; 1932-7420
• DOI: 10.1016/j.cmet.2022.09.013

In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community. Using a collaborative, multi-institutional approach, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D) studies the molecular pathogenesis of islet dysfunction in type 2 diabetes. All data generated by the program are made immediately and freely accessible, thus providing a valuable resource for the diabetes research community.