Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program
In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfun...
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| Published in | Cell metabolism Vol. 34; no. 12; pp. 1906 - 1913 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
06.12.2022
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1550-4131 1932-7420 1932-7420 |
| DOI | 10.1016/j.cmet.2022.09.013 |
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| Abstract | In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community.
Using a collaborative, multi-institutional approach, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D) studies the molecular pathogenesis of islet dysfunction in type 2 diabetes. All data generated by the program are made immediately and freely accessible, thus providing a valuable resource for the diabetes research community. |
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| AbstractList | In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community. In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community.In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community. In this perspective, we provide an overview of a recently established National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D). This program is designed to define the molecular pathogenesis of islet dysfunction by studying human pancreatic tissue samples from organ donors with T2D. HPAP-T2D generates detailed datasets of physiological, histological, transcriptomic, epigenomic, and genomic information. Importantly, all data collected, generated, and analyzed by HPAP-T2D are made immediately and freely available through a centralized database, PANC-DB, thus providing a comprehensive data resource for the diabetes research community. Using a collaborative, multi-institutional approach, the Human Pancreas Analysis Program for Type 2 Diabetes (HPAP-T2D) studies the molecular pathogenesis of islet dysfunction in type 2 diabetes. All data generated by the program are made immediately and freely accessible, thus providing a valuable resource for the diabetes research community. |
| Author | Naji, Ali Atkinson, Mark A. Kaestner, Klaus H. Shapira, Suzanne N. Powers, Alvin C. |
| Author_xml | – sequence: 1 givenname: Suzanne N. surname: Shapira fullname: Shapira, Suzanne N. organization: Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 2 givenname: Ali surname: Naji fullname: Naji, Ali organization: Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA – sequence: 3 givenname: Mark A. surname: Atkinson fullname: Atkinson, Mark A. organization: Departments of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL 32610, USA – sequence: 4 givenname: Alvin C. surname: Powers fullname: Powers, Alvin C. email: al.powers@vumc.org organization: Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA – sequence: 5 givenname: Klaus H. orcidid: 0000-0002-1228-021X surname: Kaestner fullname: Kaestner, Klaus H. email: kaestner@pennmedicine.upenn.edu organization: Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA |
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| Keywords | epigenomics type 2 diabetes pancreas islets T2D |
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| Title | Understanding islet dysfunction in type 2 diabetes through multidimensional pancreatic phenotyping: The Human Pancreas Analysis Program |
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