Sensitivity and Specificity of Plasma and Bronchoalveolar Lavage Fluid PCR for Diagnosing Pulmonary Mucormycosis in Subjects With Diabetes Mellitus

• Published in: Mycoses Vol. 68; no. 4; pp. e70063 - n/a
• Main Authors: Nawaz, Rana Sadaqat, Agarwal, Ritesh, Rudramurthy, Shivaprakash M., Choudhary, Hansraj, Harchand, Ritika, Kumar, Karthick, Sehgal, Inderpaul Singh, Kaur, Harsimran, Dhooria, Sahajal, Prasad, Kuruswamy Thurai, Prabhakar, Nidhi, Aggarwal, Ashutosh N., Muthu, Valliappan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.04.2025
• Subjects: Adult; Aged; Alveoli; Bronchoalveolar Lavage Fluid - microbiology; Bronchus; Cytology; Diabetes; Diabetes Complications - diagnosis; Diabetes Complications - microbiology; Diabetes mellitus; DNA, Fungal; Female; fungal pneumonia; Humans; Lavage; Lung Diseases, Fungal - diagnosis; Lung Diseases, Fungal - microbiology; Male; Middle Aged; Mucorales; Mucorales - genetics; Mucorales - isolation & purification; Mucormycosis; Mucormycosis - diagnosis; Mucormycosis - microbiology; Neutropenia; NGS; non‐Aspergillus moulds; PCR; Plasma; Plasma - microbiology; Polymerase chain reaction; Predictive Value of Tests; Prospective Studies; Real-Time Polymerase Chain Reaction - methods; Rhizopus; Risk factors; Sensitivity and Specificity; Mucorales; NGS; non‐Aspergillus moulds; fungal pneumonia; Rhizopus; PCR

ABSTRACT Background Mucorales polymerase chain reaction (PCR) is used to diagnose pulmonary mucormycosis (PM) among neutropenic individuals. However, data on the utility of PCR in patients with diabetes mellitus, another major risk factor for PM, are limited. Objective The primary objective was to a...