Safety, tolerability, pharmacokinetics and neutrophil elastase inhibitory effects of Sivelestat: A randomized, double-blind, placebo-controlled single- and multiple-dose escalation study in Chinese healthy subjects - Li, Kun; Dong, Lingfang; Gao, Shan; Zhang, Jingying; Feng, Yinghua; Gu, Li; Yang, Jie; Liu, Xing; Wang, Yaqin; Mao, Zhenkun; Jiang, Dandan; Xia, Zhengchao; et al. (European journal of pharmaceutical sciences, 2024)
Keywords: Area Under Curve; China; Clinical trial; Dose escalation; Dose-Response Relationship, Drug; Double-Blind Method; Glycine - analogs & derivatives; Healthy Volunteers; Humans; Leukocyte Elastase; Neutrophil elastase; Pharmacokinetics; Safety; Sivelestat; Sulfonamides; China; Clinical trial; Neutrophil elastase; Sivelestat; Safety; Dose escalation; Pharmacokinetics