Integrative metabolomics and microbiomics analysis reveals distinctive microbiota‐metabolites interactions in gastric carcinogenesis

• Published in: International journal of cancer Vol. 156; no. 12; pp. 2389 - 2400
• Main Authors: Jiang, Xiao‐Wen, Zhang, Li, Liu, Zong‐Chao, Zhou, Tong, Li, Wen‐Qing, Liu, Wei‐Dong, Zhang, Lan‐Fu, You, Wei‐Cheng, Zhang, Yang, Pan, Kai‐Feng
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.06.2025; Wiley Subscription Services, Inc
• Subjects: Aged; Carcinogenesis; Carcinogenesis - metabolism; Comparative studies; Dialister; Female; Gastric cancer; gastric lesions; Gastritis; Gastritis, Atrophic - metabolism; Gastritis, Atrophic - microbiology; Gastritis, Atrophic - pathology; Gastrointestinal Microbiome; Humans; interactions; Lactobacillus; Lecithin; Lesions; Male; Metabolism; Metabolites; Metabolome; Metabolomics; Metabolomics - methods; Metaplasia; microbes; Microbiota; Microorganisms; Middle Aged; Peptostreptococcus; Phosphatidylcholine; Phosphatidylcholines - metabolism; Phospholipase C; RNA, Ribosomal, 16S - genetics; rRNA 16S; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Triglycerides; Trinucleotide repeats; Tumorigenesis; gastric lesions; gastric cancer; microbes; metabolites; interactions

Gastric microbiota and metabolites may interact and play collaborative roles in the carcinogenesis process. This study aims to investigate differential metabolites and microbes, as well as the possible roles of microbe‐metabolite interactions in gastric cancer (GC) development. Targeted metabolomics...