Optimization of Direct Aromatic 18F-Labeling of Tetrazines

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 13; p. 4022
• Main Authors: Andersen, Ida Vang, García-Vázquez, Rocío, Battisti, Umberto Maria, Herth, Matthias M.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.06.2022; MDPI
• Subjects: Catalysts; copper-mediated fluorination; Efficiency; Fluorides; Fluorination; Fluorine; Fluorine isotopes; fluorine-18; Imaging; Labeling; Optimization; Positron emission; Precursors; pretargeted imaging; Process parameters; Radiochemistry; Radioisotopes; tetrazine ligation; Tomography

Radiolabeling of tetrazines has gained increasing attention due to their important role in pretargeted imaging or therapy. The most commonly used radionuclide in PET imaging is fluorine-18. For this reason, we have recently developed a method which enables the direct aromatic 18F-fluorination of tet...