Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications

• Published in: Drug development research Vol. 86; no. 5; pp. e70130 - n/a
• Main Authors: Peña Corona, Sheila I., Borbolla‐Jiménez, Fabiola V., Duarte‐Peña, Lorena, Moreno, Angélica, Pérez‐Caltzontzin, Luis E., Del Prado‐Audelo, María Luisa, Romero‐Montero, Alejandra, González‐Torres, Maykel, Cortés, Hernán, Hernández‐Parra, Hector, Sharifi‐Rad, Javad, Leyva‐Gómez, Gerardo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2025
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; antibiotic; Antibiotics; antimicrobial; Antimicrobial activity; Antimicrobial agents; Antimicrobial resistance; Bacteria; Bioavailability; Biofilms; Biofilms - drug effects; Block copolymers; Cell membranes; Cell walls; Disruption; Drug Repositioning; Effectiveness; Emulsifying agents; Humans; Microbicides; Microorganisms; Molecular docking; pluronic; poloxamer; Poloxamer - chemistry; Poloxamer - pharmacology; Poloxamers; Quorum sensing; antibiotic; antimicrobial; poloxamer; pluronic; antimicrobial resistance

ABSTRACT In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial th...