Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications

ABSTRACT In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial th...

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Published inDrug development research Vol. 86; no. 5; pp. e70130 - n/a
Main Authors Peña Corona, Sheila I., Borbolla‐Jiménez, Fabiola V., Duarte‐Peña, Lorena, Moreno, Angélica, Pérez‐Caltzontzin, Luis E., Del Prado‐Audelo, María Luisa, Romero‐Montero, Alejandra, González‐Torres, Maykel, Cortés, Hernán, Hernández‐Parra, Hector, Sharifi‐Rad, Javad, Leyva‐Gómez, Gerardo
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.08.2025
Subjects
Animals
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antibiotic
Antibiotics
antimicrobial
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
Bacteria
Bioavailability
Biofilms
Biofilms - drug effects
Block copolymers
Cell membranes
Cell walls
Disruption
Drug Repositioning
Effectiveness
Emulsifying agents
Humans
Microbicides
Microorganisms
Molecular docking
pluronic
poloxamer
Poloxamer - chemistry
Poloxamer - pharmacology
Poloxamers
Quorum sensing
antibiotic
antimicrobial
poloxamer
pluronic
antimicrobial resistance
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Abstract ABSTRACT In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial therapies and novel drug formulations. Poloxamers are nonionic synthetic triblock copolymers used as excipients for formulating antibiotics, mainly as emulsifying agents, gelling agents, surfactants, and humectants. It has been discovered that poloxamers may have antimicrobial activity as microbicides or micro biostatics or can also potentiate other germicide drugs' efficacy. This review aims to examine the use of poloxamers and synthesize their potential mechanisms of action as antimicrobial drugs for treating microbial infections. This review's methodology included sourcing articles from PubMed, Google Scholar, and Scopus, using specific medical subject headings terms to warranty precision and pertinence. Poloxamer action mechanisms include quorum sensing inhibition, cellular membrane disruption, bacterial biofilm inhibition, and disruptions in bacteria cell walls. Results of Molecular docking demonstrated that poloxamers could interact directly with active sites of adhesion proteins and alter their functioning. Our experimental tests showed that poloxamers 188 and 407 possess the potential to be antimicrobial agents by effectively inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth. Despite the convincing evidence, further research is required to overcome challenges related to poloxamers' bioavailability and establish effective dosing regimens for different poloxamers to warrant their use and safety as antimicrobial drugs.
AbstractList In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial therapies and novel drug formulations. Poloxamers are nonionic synthetic triblock copolymers used as excipients for formulating antibiotics, mainly as emulsifying agents, gelling agents, surfactants, and humectants. It has been discovered that poloxamers may have antimicrobial activity as microbicides or micro biostatics or can also potentiate other germicide drugs' efficacy. This review aims to examine the use of poloxamers and synthesize their potential mechanisms of action as antimicrobial drugs for treating microbial infections. This review's methodology included sourcing articles from PubMed, Google Scholar, and Scopus, using specific medical subject headings terms to warranty precision and pertinence. Poloxamer action mechanisms include quorum sensing inhibition, cellular membrane disruption, bacterial biofilm inhibition, and disruptions in bacteria cell walls. Results of Molecular docking demonstrated that poloxamers could interact directly with active sites of adhesion proteins and alter their functioning. Our experimental tests showed that poloxamers 188 and 407 possess the potential to be antimicrobial agents by effectively inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth. Despite the convincing evidence, further research is required to overcome challenges related to poloxamers' bioavailability and establish effective dosing regimens for different poloxamers to warrant their use and safety as antimicrobial drugs.
ABSTRACT In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial therapies and novel drug formulations. Poloxamers are nonionic synthetic triblock copolymers used as excipients for formulating antibiotics, mainly as emulsifying agents, gelling agents, surfactants, and humectants. It has been discovered that poloxamers may have antimicrobial activity as microbicides or micro biostatics or can also potentiate other germicide drugs' efficacy. This review aims to examine the use of poloxamers and synthesize their potential mechanisms of action as antimicrobial drugs for treating microbial infections. This review's methodology included sourcing articles from PubMed, Google Scholar, and Scopus, using specific medical subject headings terms to warranty precision and pertinence. Poloxamer action mechanisms include quorum sensing inhibition, cellular membrane disruption, bacterial biofilm inhibition, and disruptions in bacteria cell walls. Results of Molecular docking demonstrated that poloxamers could interact directly with active sites of adhesion proteins and alter their functioning. Our experimental tests showed that poloxamers 188 and 407 possess the potential to be antimicrobial agents by effectively inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth. Despite the convincing evidence, further research is required to overcome challenges related to poloxamers' bioavailability and establish effective dosing regimens for different poloxamers to warrant their use and safety as antimicrobial drugs.
In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial therapies and novel drug formulations. Poloxamers are nonionic synthetic triblock copolymers used as excipients for formulating antibiotics, mainly as emulsifying agents, gelling agents, surfactants, and humectants. It has been discovered that poloxamers may have antimicrobial activity as microbicides or micro biostatics or can also potentiate other germicide drugs' efficacy. This review aims to examine the use of poloxamers and synthesize their potential mechanisms of action as antimicrobial drugs for treating microbial infections. This review's methodology included sourcing articles from PubMed, Google Scholar, and Scopus, using specific medical subject headings terms to warranty precision and pertinence. Poloxamer action mechanisms include quorum sensing inhibition, cellular membrane disruption, bacterial biofilm inhibition, and disruptions in bacteria cell walls. Results of Molecular docking demonstrated that poloxamers could interact directly with active sites of adhesion proteins and alter their functioning. Our experimental tests showed that poloxamers 188 and 407 possess the potential to be antimicrobial agents by effectively inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth. Despite the convincing evidence, further research is required to overcome challenges related to poloxamers' bioavailability and establish effective dosing regimens for different poloxamers to warrant their use and safety as antimicrobial drugs.In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated with around 4.95 million deaths per year worldwide. Control of this resistance represents the biggest challenge for antimicrobial therapies and novel drug formulations. Poloxamers are nonionic synthetic triblock copolymers used as excipients for formulating antibiotics, mainly as emulsifying agents, gelling agents, surfactants, and humectants. It has been discovered that poloxamers may have antimicrobial activity as microbicides or micro biostatics or can also potentiate other germicide drugs' efficacy. This review aims to examine the use of poloxamers and synthesize their potential mechanisms of action as antimicrobial drugs for treating microbial infections. This review's methodology included sourcing articles from PubMed, Google Scholar, and Scopus, using specific medical subject headings terms to warranty precision and pertinence. Poloxamer action mechanisms include quorum sensing inhibition, cellular membrane disruption, bacterial biofilm inhibition, and disruptions in bacteria cell walls. Results of Molecular docking demonstrated that poloxamers could interact directly with active sites of adhesion proteins and alter their functioning. Our experimental tests showed that poloxamers 188 and 407 possess the potential to be antimicrobial agents by effectively inhibiting Staphylococcus aureus and Pseudomonas aeruginosa growth. Despite the convincing evidence, further research is required to overcome challenges related to poloxamers' bioavailability and establish effective dosing regimens for different poloxamers to warrant their use and safety as antimicrobial drugs.
Author Leyva‐Gómez, Gerardo
Borbolla‐Jiménez, Fabiola V.
Moreno, Angélica
Duarte‐Peña, Lorena
Del Prado‐Audelo, María Luisa
Cortés, Hernán
Romero‐Montero, Alejandra
Peña Corona, Sheila I.
Pérez‐Caltzontzin, Luis E.
Hernández‐Parra, Hector
Sharifi‐Rad, Javad
González‐Torres, Maykel
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  surname: Cortés
  fullname: Cortés, Hernán
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  fullname: Hernández‐Parra, Hector
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antimicrobial
poloxamer
pluronic
antimicrobial resistance
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Snippet ABSTRACT In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon...
In the last decades, the misuse and overuse of antimicrobial medications have precipitated the appearance of antimicrobial resistance, a phenomenon associated...
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SubjectTerms Animals
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antibiotic
Antibiotics
antimicrobial
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
Bacteria
Bioavailability
Biofilms
Biofilms - drug effects
Block copolymers
Cell membranes
Cell walls
Disruption
Drug Repositioning
Effectiveness
Emulsifying agents
Humans
Microbicides
Microorganisms
Molecular docking
pluronic
poloxamer
Poloxamer - chemistry
Poloxamer - pharmacology
Poloxamers
Quorum sensing
Title Repurposing Poloxamers as Antimicrobial Agents: A Comprehensive Review of Mechanisms and Applications
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fddr.70130
https://www.ncbi.nlm.nih.gov/pubmed/40719268
https://www.proquest.com/docview/3238981312
https://www.proquest.com/docview/3234307615
Volume 86
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