High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors

• Published in: The Journal of experimental medicine Vol. 215; no. 10; pp. 2520 - 2535
• Main Authors: Brummelman, Jolanda, Mazza, Emilia M.C., Alvisi, Giorgia, Colombo, Federico S., Grilli, Andrea, Mikulak, Joanna, Mavilio, Domenico, Alloisio, Marco, Ferrari, Francesco, Lopci, Egesta, Novellis, Pierluigi, Veronesi, Giulia, Lugli, Enrico
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.10.2018

CD8+ T cells infiltrating tumors are largely dysfunctional, but whether a subset maintains superior functionality remains ill defined. By high-dimensional single cell analysis of millions of CD8+ T cells from 53 individuals with lung cancer, we defined those subsets that are enriched in tumors compa...