A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin

• Published in: Microbial pathogenesis Vol. 15; no. 5; pp. 327 - 346
• Main Authors: Kapur, Vivek, Topouzis, Stavros, Majesky, Mark W., Li, Ling-Ling, Hamrick, Marcie R., Hamill, Richard J., Patti, Joseph M., Musser, James M.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier India Pvt Ltd 01.11.1993; Elsevier
• Subjects: Alleles; Bacterial Proteins - metabolism; Bacteriology; Base Sequence; Biological and medical sciences; Cells, Cultured; Codon; Cysteine Endopeptidases - metabolism; Endothelium, Vascular - cytology; Extracellular Matrix - metabolism; extracellular matrix proteins; Fibronectins - metabolism; Fundamental and applied biological sciences. Psychology; Genes, Bacterial; Glycoproteins - metabolism; group A streptococci; Humans; Metabolism. Enzymes; Microbiology; molecular evolution; Molecular Sequence Data; multilocus enzyme electrophoresis; Phylogeny; Point Mutation; Sequence Alignment; Sequence Deletion; Sequence Homology, Nucleic Acid; Streptococcal Infections - microbiology; Streptococcal Infections - prevention & control; Streptococcus pyogenes; Streptococcus pyogenes - enzymology; Streptococcus pyogenes - genetics; Streptococcus pyogenes - isolation & purification; Streptococcus pyogenes - pathogenicity; Substrate Specificity; Vitronectin; extracellular matrix proteins; multilocus enzyme electrophoresis; molecular evolution; group A streptococci; Human; Enzyme; Cysteine endopeptidases; Cell adhesion molecule; Vitronectin; Glycoproteins; Dendrogram; Extracellular; Fibronectin; Streptococcaceae; Molecular evolution; Allele; Enzymatic activity; Proteolysis; Bacteria; Hydrolases; Micrococcales; Streptococcus pyogenes; Proteinases; Polymorphism

Streptococcus pyogenes secretes an extracellular cysteine protease that cleaves human interleukin 1β precursor to form biologically active IL 1β, a major cytokine mediating inflammation and shock. To further investigate the potential role of the cysteine protease in host-parasite interactions, the e...