Hyperlactatemia is associated with increased risks of long-term mortality and major adverse cardiovascular events in sepsis survivors
Serum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality risks. However, the associations between hyperlactatemia and long-term clinical outcomes in sepsis survivors remain unknown. The objecti...
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Published in | Infectious diseases (London, England) Vol. 55; no. 8; pp. 576 - 584 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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England
Taylor & Francis
03.08.2023
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Abstract | Serum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality risks. However, the associations between hyperlactatemia and long-term clinical outcomes in sepsis survivors remain unknown. The objective of this study was to investigate whether hyperlactatemia at the time of hospitalisation for sepsis was associated with worse long-term clinical outcomes in sepsis survivors.
In total, of 4983 sepsis survivors aged ≥ 20 years were enrolled in this study between January 1, 2012, and December 31, 2018. They were divided into low (≤18 mg/dL; n = 2698) and high (>18 mg/dL; n = 2285) lactate groups. The high lactate group was then matched 1:1 by propensity-score method to the low lactate group. The outcomes of interest were all-cause mortality, major adverse cardiac events (MACEs), ischaemic stroke, myocardial infarction, hospitalisation for heart failure, and end-stage renal disease.
After propensity score matching, the high lactate group had greater risks of all-cause mortality (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.41-1.67), MACEs (HR 1.53, 95% CI 1.29-1.81), ischaemic stroke (HR 1.47, 95% CI 1.19-1.81), myocardial infarction (HR 1.52, 95% CI 1.17-1.99), and end-stage renal disease (HR 1.42, 95% CI 1.16-1.72). Subgroup analyses stratified by baseline renal function revealed almost similarity across groups.
We found that hyperlactatemia is associated with long-term risks of mortality and MACEs in sepsis survivors. Physicians may consider more aggressive and prompter management of sepsis in patients who present with hyperlactatemia to improve long-term prognoses. |
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AbstractList | Serum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality risks. However, the associations between hyperlactatemia and long-term clinical outcomes in sepsis survivors remain unknown. The objective of this study was to investigate whether hyperlactatemia at the time of hospitalisation for sepsis was associated with worse long-term clinical outcomes in sepsis survivors.
In total, of 4983 sepsis survivors aged ≥ 20 years were enrolled in this study between January 1, 2012, and December 31, 2018. They were divided into low (≤18 mg/dL; n = 2698) and high (>18 mg/dL; n = 2285) lactate groups. The high lactate group was then matched 1:1 by propensity-score method to the low lactate group. The outcomes of interest were all-cause mortality, major adverse cardiac events (MACEs), ischaemic stroke, myocardial infarction, hospitalisation for heart failure, and end-stage renal disease.
After propensity score matching, the high lactate group had greater risks of all-cause mortality (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.41-1.67), MACEs (HR 1.53, 95% CI 1.29-1.81), ischaemic stroke (HR 1.47, 95% CI 1.19-1.81), myocardial infarction (HR 1.52, 95% CI 1.17-1.99), and end-stage renal disease (HR 1.42, 95% CI 1.16-1.72). Subgroup analyses stratified by baseline renal function revealed almost similarity across groups.
We found that hyperlactatemia is associated with long-term risks of mortality and MACEs in sepsis survivors. Physicians may consider more aggressive and prompter management of sepsis in patients who present with hyperlactatemia to improve long-term prognoses. Serum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality risks. However, the associations between hyperlactatemia and long-term clinical outcomes in sepsis survivors remain unknown. The objective of this study was to investigate whether hyperlactatemia at the time of hospitalisation for sepsis was associated with worse long-term clinical outcomes in sepsis survivors. In total, of 4983 sepsis survivors aged ≥ 20 years were enrolled in this study between January 1, 2012, and December 31, 2018. They were divided into low (≤18 mg/dL; = 2698) and high (>18 mg/dL; = 2285) lactate groups. The high lactate group was then matched 1:1 by propensity-score method to the low lactate group. The outcomes of interest were all-cause mortality, major adverse cardiac events (MACEs), ischaemic stroke, myocardial infarction, hospitalisation for heart failure, and end-stage renal disease. After propensity score matching, the high lactate group had greater risks of all-cause mortality (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.41-1.67), MACEs (HR 1.53, 95% CI 1.29-1.81), ischaemic stroke (HR 1.47, 95% CI 1.19-1.81), myocardial infarction (HR 1.52, 95% CI 1.17-1.99), and end-stage renal disease (HR 1.42, 95% CI 1.16-1.72). Subgroup analyses stratified by baseline renal function revealed almost similarity across groups. We found that hyperlactatemia is associated with long-term risks of mortality and MACEs in sepsis survivors. Physicians may consider more aggressive and prompter management of sepsis in patients who present with hyperlactatemia to improve long-term prognoses. INTRODUCTIONSerum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term mortality risks. However, the associations between hyperlactatemia and long-term clinical outcomes in sepsis survivors remain unknown. The objective of this study was to investigate whether hyperlactatemia at the time of hospitalisation for sepsis was associated with worse long-term clinical outcomes in sepsis survivors. METHODSIn total, of 4983 sepsis survivors aged ≥ 20 years were enrolled in this study between January 1, 2012, and December 31, 2018. They were divided into low (≤18 mg/dL; n = 2698) and high (>18 mg/dL; n = 2285) lactate groups. The high lactate group was then matched 1:1 by propensity-score method to the low lactate group. The outcomes of interest were all-cause mortality, major adverse cardiac events (MACEs), ischaemic stroke, myocardial infarction, hospitalisation for heart failure, and end-stage renal disease. RESULTSAfter propensity score matching, the high lactate group had greater risks of all-cause mortality (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.41-1.67), MACEs (HR 1.53, 95% CI 1.29-1.81), ischaemic stroke (HR 1.47, 95% CI 1.19-1.81), myocardial infarction (HR 1.52, 95% CI 1.17-1.99), and end-stage renal disease (HR 1.42, 95% CI 1.16-1.72). Subgroup analyses stratified by baseline renal function revealed almost similarity across groups. CONCLUSIONWe found that hyperlactatemia is associated with long-term risks of mortality and MACEs in sepsis survivors. Physicians may consider more aggressive and prompter management of sepsis in patients who present with hyperlactatemia to improve long-term prognoses. |
Author | Chou, Yu-Mei Chia, Yuan-Yi Ou, Shu-Yu Sun, Gwo-Ching Lee, Yi-Jung |
Author_xml | – sequence: 1 givenname: Shu-Yu surname: Ou fullname: Ou, Shu-Yu organization: Department of Anesthesiology, Kaohsiung Veterans General Hospital – sequence: 2 givenname: Yi-Jung surname: Lee fullname: Lee, Yi-Jung organization: School of Medicine, National Yang Ming Chiao Tung University – sequence: 3 givenname: Yu-Mei surname: Chou fullname: Chou, Yu-Mei organization: Department of Anesthesiology, Kaohsiung Veterans General Hospital – sequence: 4 givenname: Gwo-Ching surname: Sun fullname: Sun, Gwo-Ching organization: Institute of Clinical Medicine, National Cheng Kung University – sequence: 5 givenname: Yuan-Yi surname: Chia fullname: Chia, Yuan-Yi organization: School of Nursing, Fooyin University |
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Cites_doi | 10.5935/0103-507X.20130047 10.1016/j.resuscitation.2011.06.015 10.1053/j.ajkd.2010.02.344 10.1056/NEJMra1208623 10.1097/01.ccm.0000132904.35713.a7 10.1186/s13054-015-1014-6 10.1378/chest.11-0352 10.3389/fnut.2021.783164 10.1001/jamapediatrics.2016.3681 10.1164/rccm.201510-2023OC 10.1097/CCM.0000000000000742 10.1097/SHK.0000000000000772 10.1186/s13054-018-2186-7 10.1186/1757-7241-19-74 10.1001/jama.2016.0287 10.1016/j.annemergmed.2004.12.006 10.1007/s40121-023-00765-6 10.1177/1178633719862776 10.1007/s00134-007-0563-9 10.1001/jama.2012.3954 10.3389/fmed.2022.809292 10.1038/s41598-021-99581-6 10.1186/s13613-021-00893-7 10.1186/s13613-021-00937-y 10.1186/2110-5820-3-6 10.1186/s13054-014-0503-3 10.5935/0103-507X.20170021 10.1186/s13054-016-1403-5 10.4143/crt.2018.360 10.1186/s13049-017-0415-8 10.4103/0970-9185.81819 10.1161/JAHA.122.028882 10.1053/j.ajkd.2012.06.016 10.3947/ic.2017.49.1.10 |
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Snippet | Serum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated short-term... INTRODUCTIONSerum lactate is a potentially valuable biomarker for risk assessment for patients with sepsis, as hyperlactatemia is associated with elevated... |
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SubjectTerms | Brain Ischemia - complications End-stage renal disease Humans hyperlactatemia Hyperlactatemia - complications Hyperlactatemia - epidemiology Ischemic Stroke - complications Kidney Failure, Chronic - complications Lactic Acid major adverse cardiac events mortality Myocardial Infarction - complications sepsis Sepsis - complications Sepsis - epidemiology sepsis survivor Stroke - complications Survivors |
Title | Hyperlactatemia is associated with increased risks of long-term mortality and major adverse cardiovascular events in sepsis survivors |
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