How Progesterone Receptor Expression Impacts Platinum Sensitivity in Ovarian Clear Cell Carcinoma: Insights from Clinical and Experimental Perspectives

• Published in: International journal of molecular sciences Vol. 25; no. 14; p. 7942
• Main Authors: Wu, Chen-Hsuan, Fu, Hung-Chun, Ou, Yu-Che, Chuang, I-Chieh, Lan, Jui, Yang, Ming-Yu, Lin, Hao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.07.2024
• Subjects: Adenocarcinoma, Clear Cell - drug therapy; Adenocarcinoma, Clear Cell - genetics; Adenocarcinoma, Clear Cell - metabolism; Adenocarcinoma, Clear Cell - pathology; Adult; Aged; Antibodies; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cancer therapies; Cell Line, Tumor; Cell Movement - drug effects; Cells; Chemotherapy; Cisplatin - pharmacology; Cisplatin - therapeutic use; Cytotoxicity; Drug Resistance, Neoplasm - genetics; Endometriosis; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; Medical prognosis; Middle Aged; Ovarian cancer; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Platinum - pharmacology; Platinum - therapeutic use; Proteins; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Retrospective Studies; Taiwan; ovarian clear cell carcinoma; progesterone receptor; platinum sensitivity

Ovarian clear cell carcinoma (OCCC) is often considered a relatively platinum-resistant malignancy. The aim of this study was to explore the influence of progesterone receptor (PR) expression levels on platinum sensitivity and survival outcomes in people with OCCC. A retrospective analysis was condu...