A note on the probability structure of a doubly randomized delayed start design

• Published in: Statistical theory and related fields Vol. 9; no. 2; pp. 141 - 148
• Main Author: Yang, Zhao
• Format: Journal Article
• Language: English
• Published: Taylor & Francis Group 03.04.2025
• Subjects: Doubly randomized delayed start; placebo effect; sequential parallel comparison design; truncation

The innovative doubly randomized delayed start (DRDS) design has been implemented to tackle the well-known challenge of a high placebo response rate in clinical trials. This design begins with a conventional parallel design phase (period 1), followed by a subsequent phase (period 2) where subjects i...