Infliximab Reverses Symptoms and May Protect from Developing Chronic Restrictive Ophthalmopathy in Children with Familial Orbital Myositis: A Case Report

• Published in: Ocular immunology and inflammation Vol. 31; no. 5; pp. 1097 - 1100
• Main Authors: Huynh, Aimee, Siggs, Owen M., Wainstein, Brynn K., Gray, Paul E.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 28.05.2023
• Subjects: Adult; Australia; Autosomal dominant; Child; children; Diplopia - complications; familial; Humans; Inflammation - complications; infliximab; Infliximab - therapeutic use; Orbital Diseases - diagnosis; orbital myositis; Orbital Myositis - diagnosis; Orbital Myositis - drug therapy; Orbital Myositis - etiology; Tumor Necrosis Factor Inhibitors; Australia; Autosomal dominant; familial; orbital myositis; children; infliximab

Orbital myositis is a rare sporadic eye disease associated with extraocular eye muscle inflammation. To date, there have been two reports of familial orbital myositis (FOM), which demonstrate partially penetrant autosomal dominant inheritance. We report six new Australian cases of FOM, four of whom...