Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

• Published in: The Journal of biological chemistry Vol. 271; no. 32; pp. 19612 - 19616
• Main Authors: Brostjan, Christine, Anrather, Josef, Csizmadia, Vilmos, Stroka, Deborah, Soares, Miguel, Bach, Fritz H., Winkler, Hans
• Format: Journal Article
• Language: English
• Published: 1996

Repression of NF Kappa B-dependent gene expression is one of the major elements of immunosuppression by glucocorticoids. Protein-protein interactions between the glucocorticoid receptor and NF Kappa B have been characterized and shown to be a possible mechanism of mutual inhibition of transactivatio...