Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain

• Published in: Neurotoxicity research Vol. 3; no. 4; pp. 339 - 349
• Main Authors: Rosenbrock, H, Hagemeyer, C E, Ditter, M, Knoth, R, Volk, B
• Format: Journal Article
• Language: English
• Published: United States 01.07.2001

Several cytochrome P450 subfamilies are inducible by specific exogenous compounds like the antiepileptic drug phenytoin. Some of these P450 enzymes are involved in the metabolism of gonadal hormones also contributing to neuronal differentiation. CYP3A enzymes have the capacity to catalyze the hydrox...