Downregulation of β1 Integrins by Ebola Virus Glycoprotein: Implication for Virus Entry

• Published in: Virology (New York, N.Y.) Vol. 278; no. 1; pp. 20 - 26
• Main Authors: Takada, Ayato, Watanabe, Shinji, Ito, Hiroshi, Okazaki, Katsunori, Kida, Hiroshi, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.12.2000

Filoviruses, including Ebola virus, are cytotoxic. To investigate the role of the Ebola virus glycoprotein (GP) in this cytopathic effect, we transiently expressed the GP in human kidney 293T cells. Expression of wild-type GP, but not the secretory form of the molecule lacking a membrane anchor, ind...