Identification of H209 as Essential for pH 8-Triggered Receptor-Independent Syncytium Formation by S Protein of Mouse Hepatitis Virus A59

• Published in: Journal of virology Vol. 92; no. 11
• Main Authors: Li, Pei, Shan, Yiwei, Zheng, Wangliang, Ou, Xiuyuan, Mi, Dan, Mu, Zhixia, Holmes, Kathryn V, Qian, Zhaohui
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.06.2018
• Subjects: Virus-Cell Interactions; coronavirus spike glycoprotein; coronavirus receptor-independent syncytium formation; mouse hepatitis virus; S protein conformational change; coronavirus S glycoprotein thermal stability

The spike glycoprotein (S) of murine coronavirus mouse hepatitis virus (MHV) strain A59 uses murine carcinoembryonic antigen-related cell adhesion molecule 1a as its receptor for cell entry, but S protein can also be triggered in the absence of receptor by pH 8.0 alone at 37°C. The mechanism by whic...