Assessment of early therapeutic response to sorafenib in renal cell carcinoma xenografts by dynamic contrast-enhanced and diffusion-weighted MR imaging
To investigate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) in monitoring early therapeutic response to sorafenib in renal cell carcinoma (RCC) xenograft models. Sorafenib (40 mg kg(-1)) was administered orally to BALB/c nude mice (n = 9) bearing subcut...
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Published in | British journal of radiology Vol. 88; no. 1053; p. 20150163 |
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01.09.2015
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Abstract | To investigate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) in monitoring early therapeutic response to sorafenib in renal cell carcinoma (RCC) xenograft models.
Sorafenib (40 mg kg(-1)) was administered orally to BALB/c nude mice (n = 9) bearing subcutaneous tumours of human RCC ACHN xenografts. DCE-MRI and DWI were obtained 0, 1, 3 and 7 days after therapy, and DCE-MRI parameters (K(trans) and ve) and apparent diffusion coefficient (ADC) values were calculated. Tumour size and volume changes were correlated with changes in DCE-MRI parameters or ADC values after therapy.
Following therapy, K(trans) showed a significant decrease over time (p = 0.005), whereas ve did not demonstrate significant changes between time points (p = 0.97). ADC values showed a progressive increase over time (p = 0.004). Compared with pre-therapy, K(trans) showed a significant decrease after 3 days of therapy (p = 0.039), and ADC values increased significantly after 7 days (p = 0.039). Tumour size and volume did not show significant changes during 7 days. Tumour size and volume changes were not associated with changes in DCE-MRI parameters or ADC values.
DCE-MRI and DWI may show early physiological changes within 1 week after initiating sorafenib treatment on human RCC xenografts.
The quantitative parameters of DCE-MRI and DWI may offer the potential for assessing early therapeutic response to sorafenib in clinical trials. |
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AbstractList | OBJECTIVETo investigate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) in monitoring early therapeutic response to sorafenib in renal cell carcinoma (RCC) xenograft models.METHODSSorafenib (40 mg kg(-1)) was administered orally to BALB/c nude mice (n = 9) bearing subcutaneous tumours of human RCC ACHN xenografts. DCE-MRI and DWI were obtained 0, 1, 3 and 7 days after therapy, and DCE-MRI parameters (K(trans) and ve) and apparent diffusion coefficient (ADC) values were calculated. Tumour size and volume changes were correlated with changes in DCE-MRI parameters or ADC values after therapy.RESULTSFollowing therapy, K(trans) showed a significant decrease over time (p = 0.005), whereas ve did not demonstrate significant changes between time points (p = 0.97). ADC values showed a progressive increase over time (p = 0.004). Compared with pre-therapy, K(trans) showed a significant decrease after 3 days of therapy (p = 0.039), and ADC values increased significantly after 7 days (p = 0.039). Tumour size and volume did not show significant changes during 7 days. Tumour size and volume changes were not associated with changes in DCE-MRI parameters or ADC values.CONCLUSIONDCE-MRI and DWI may show early physiological changes within 1 week after initiating sorafenib treatment on human RCC xenografts.ADVANCES IN KNOWLEDGEThe quantitative parameters of DCE-MRI and DWI may offer the potential for assessing early therapeutic response to sorafenib in clinical trials. To investigate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DWI) in monitoring early therapeutic response to sorafenib in renal cell carcinoma (RCC) xenograft models. Sorafenib (40 mg kg(-1)) was administered orally to BALB/c nude mice (n = 9) bearing subcutaneous tumours of human RCC ACHN xenografts. DCE-MRI and DWI were obtained 0, 1, 3 and 7 days after therapy, and DCE-MRI parameters (K(trans) and ve) and apparent diffusion coefficient (ADC) values were calculated. Tumour size and volume changes were correlated with changes in DCE-MRI parameters or ADC values after therapy. Following therapy, K(trans) showed a significant decrease over time (p = 0.005), whereas ve did not demonstrate significant changes between time points (p = 0.97). ADC values showed a progressive increase over time (p = 0.004). Compared with pre-therapy, K(trans) showed a significant decrease after 3 days of therapy (p = 0.039), and ADC values increased significantly after 7 days (p = 0.039). Tumour size and volume did not show significant changes during 7 days. Tumour size and volume changes were not associated with changes in DCE-MRI parameters or ADC values. DCE-MRI and DWI may show early physiological changes within 1 week after initiating sorafenib treatment on human RCC xenografts. The quantitative parameters of DCE-MRI and DWI may offer the potential for assessing early therapeutic response to sorafenib in clinical trials. |
Author | Kim, J-H Lee, J H Kim, C K Park, B K Jeon, T Y Im, G H |
Author_xml | – sequence: 1 givenname: T Y surname: Jeon fullname: Jeon, T Y organization: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea – sequence: 2 givenname: C K surname: Kim fullname: Kim, C K organization: 2 Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea – sequence: 3 givenname: J-H surname: Kim fullname: Kim, J-H organization: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea – sequence: 4 givenname: G H surname: Im fullname: Im, G H organization: 3 Department of Radiology and Center for Molecular and Cellular Imaging, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea – sequence: 5 givenname: B K surname: Park fullname: Park, B K organization: 1 Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea – sequence: 6 givenname: J H surname: Lee fullname: Lee, J H organization: 3 Department of Radiology and Center for Molecular and Cellular Imaging, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea |
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References | 15466206 - Cancer Res. 2004 Oct 1;64(19):7099-109 19770299 - AJR Am J Roentgenol. 2009 Oct;193(4):W301-7 15483011 - J Clin Oncol. 2004 Nov 15;22(22):4442-5 17255307 - Clin Cancer Res. 2007 Jan 15;13(2 Pt 2):764s-769s 17160391 - Cancer Chemother Pharmacol. 2007 Apr;59(5):561-74 18824708 - J Clin Oncol. 2008 Oct 1;26(28):4572-8 18710982 - Radiology. 2008 Sep;248(3):894-900 10931592 - J Magn Reson Imaging. 2000 Aug;12(2):289-96 16418310 - Ann Oncol. 2006 Aug;17(8):1185-96 15868426 - Breast Cancer Res Treat. 2005 May;91(1):1-10 23255750 - AJR Am J Roentgenol. 2013 Jan;200(1):120-6 16916701 - Magn Reson Imaging. 2006 Sep;24(7):843-7 18219225 - Cancer Biol Ther. 2008 Apr;7(4):496-501 17296704 - J Vasc Interv Radiol. 2007 Jan;18(1 Pt 1):49-56 17215530 - N Engl J Med. 2007 Jan 11;356(2):125-34 19186405 - Neoplasia. 2009 Feb;11(2):102-25 11161148 - Radiology. 2001 Feb;218(2):365-74 21954069 - NMR Biomed. 2012 Apr;25(4):674-84 19474376 - Radiology. 2009 Jun;251(3):731-42 12637476 - J Clin Oncol. 2003 Mar 15;21(6):1094-100 16616487 - Eur J Cancer. 2006 May;42(8):1031-9 22188900 - J Transl Med. 2011;9:220 17189398 - Clin Cancer Res. 2006 Dec 15;12(24):7271-8 14531000 - Eur Radiol. 2004 Feb;14(2):309-17 15087722 - Invest Radiol. 2004 May;39(5):277-87 23908122 - J Magn Reson Imaging. 2013 Nov;38(5):1043-53 17827460 - J Clin Oncol. 2007 Sep 10;25(26):4104-9 23188618 - J Magn Reson Imaging. 2013 Jul;38(1):119-26 14612898 - Br J Cancer. 2003 Nov 17;89(10):1889-95 3626789 - Magn Reson Imaging. 1987;5(3):201-8 22653283 - Eur Radiol. 2012 Nov;22(11):2533-9 21496446 - Mol Imaging. 2011 Jun;10(3):153-67 b10 b32 b12 b11 b14 b13 b16 b15 b18 b17 b19 b1 b2 b3 b4 b5 b6 b7 b8 b9 b21 b20 b23 b22 b25 b24 b27 b26 b29 b28 Kim H (b31) 2011; 10 b30 |
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SubjectTerms | Animals Biomarkers, Tumor - metabolism Carcinoma, Renal Cell - drug therapy Contrast Media Diffusion Magnetic Resonance Imaging - methods Disease Models, Animal Feasibility Studies Genitourinary Tract Kidney Neoplasms - drug therapy Magnetic Resonance Imaging - methods Male Mice Mice, Nude Niacinamide - analogs & derivatives Niacinamide - therapeutic use Phenylurea Compounds - therapeutic use Prognosis Protein Kinase Inhibitors - therapeutic use Reproducibility of Results Sensitivity and Specificity Treatment Outcome |
Title | Assessment of early therapeutic response to sorafenib in renal cell carcinoma xenografts by dynamic contrast-enhanced and diffusion-weighted MR imaging |
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